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The results obtained from standardization of leaves estabilished
the macro and microscopic parameters, physicochemical parameters,
HPTLC and HPLC profiles that characterize the genuine plant drug
Vitex agnus castus.These parameters can be utilized for quick
identification of drug and are particularly useful in case of
powdered materials.The findings reveal significant activity of
plant in acute, sub-acute and chronic models for inflammation.Also,
probable mechanism of inflammation has been elucidated by IL- 6 and
TNF- estimation.The findings also reveal significant antioxidant
activity of plant assessed by various in-vitro and in-vivo
models.The findings also established the correlation between
antioxidant and chronic antiinflammatory activity and possible
chemical mediators involved for antioxidant and antiinflammatory
activity.The extracts also showed inhibition of IL-6, TNF- .The
antioxidant property makes it suitable for chronic and prolonged
administration required for treatment of chronic inflammatory
process.The toxicity profile of the plant can be used for designing
preclinical and clinical studies.
Increase in scientific investigations into indigenious wealth of
herbal medicines gives ample evidence of medicinal plants as
sources of drugs. Hepatocellular Carcinoma represents about 4% of
all malignancies worldwide.Plants contain chemopreventive agents
like phenolic compounds, nitrogen compounds and some other
endogenous metabolites, which are rich in antioxidant activity.
Thioacetamide, a model hepatotoxicant, initiates hepatocellular
necrosis and further hepatocarcinogenesis. Thioacetamide thus
produces oxidative stress on liver and causes hepatocellular
carcinoma. This oxidative stress can be reversed by the use of
antioxidants. Thus, the aim of this work was to evaluate the
anticancer activity of hydroalcoholic extract prepared from
Casearia esculenta, correlating the biochemical and histological
changes in thioacetamide induced hepatocellular carcinoma in female
Sprague Dawley rats. This research work should help shed some light
on cancer research and experimental model development for
hepatocellular carcinoma, and should be especially useful to
research scholars, scientists and students working on
hepatocellular carcinoma in experimental animals.
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Glycyrrhiza glabra (Paperback)
Monika Dilip Thatte, Kala Suhas Kulkarni, Kishori Ganpat Apte
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R1,220
Discovery Miles 12 200
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Ships in 10 - 15 working days
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Over the past few years, extensive research is being carried out on
the potential therapeutic benefits of medicinal plants. One such
medicinal plant of interest is that of Glycyrrhiza glabra, commonly
known as 'Licorice'. This book, provides the information and data
of the preclinical studies carried out on Glycyrrhiza glabra.
Toxicity studies carried out included, acute toxicity, subchronic
toxicity and fish toxicity. Glycyrrhiza glabra was also evaluated
for its anti-obesity, anti-fertility, anti-microbial and
anti-cancer activity. The book, therefore provides some data which
will be useful in areas of herbal drug industry, Indian system of
medicine and homeopathy, complementary medicine and drug discovery.
Medicinal plant preparations have found widespread use particularly
in the case of diseases not amenable to treatment by modern
methods. Semecarpus anacardium (SA) linn (Family: Anacardiaceae),
is a plant well-known for its medicinal value in ayurvedic and
siddha system of medicine. Chemical and phytochemical analyses of
Semecarpus anacardium nut reveal the presence of biflavonoids,
phenolic compounds, bhilawanols, minerals, vitamins and amino
acids. The results of preclinical and toxicity study provide the
necessary data for further clinical trials in immunomodulatory
disorders with SA nut as an 'add on' therapy to established
immunomodultory agents. Semecarpus anacardium can be a potential
complementary in drug therapy as immunomodulator in cancer therapy.
Hepatocellular Carcinoma represents about 4% of all malignancies
worldwide. A number of chemopreventive phytochemicals have been
identified which react with prooxidants and prevent damages to DNA
thereby preventing the onset of various diseases. Thioacetamide, a
model hepatotoxicant, undergoes metabolic activation to form
thioacetamide sulfoxide and further metabolized to form
thioacetamide-S, S, - oxide thus initiating hepatocellular necrosis
and further hepatocarcinogenesis. Thioacetamide thus produces
oxidative stress on liver and causes hepatocellular carcinoma. This
oxidative stress can be reversed by the use of antioxidants. Thus,
the aim of this work was to evaluate the anticancer activity of
hydroalcoholic extract prepared from Oroxylum indicum, correlating
the biochemical and histological changes in thioacetamide induced
hepatocellular carcinoma in female Sprague Dawley rats. This
research work should help shed some light on cancer research and
experimental model development for hepatocellular carcinoma, and
should be especially useful to research scholars, scientists and
students working on hepatocellular carcinoma in experimental
animals.
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