Advanced Issue Resolution in Safety Pharmacology not only discusses unique issues that may emerge during the development of new medicines, but also provides detailed insights on how to resolve them. The book employs a valuable strategy that integrates preclinical findings with the clinical resolution of those findings. In addition, it introduces key interdisciplinary topics in an accessible and systematic format. Edited and written by leaders in the field of safety pharmacology, this book considerably advances the discussion on issue resolution topics, thus raising them to the next level of importance by providing scientists with an indispensable resource on solving safety issues.

Michel Foucault is famous as one of the 20th-century's most innovative thinkers - and his work on Discipline and Punish was so original and offered models so useful to other scholars that the book now ranks among the most influential academic works ever published. Foucault's aim is to trace the way in which incarceration was transformed between the seventeenth and twentieth centuries. What started as a spectacle, in which ritual punishments were focused on the prisoner's body, eventually became a matter of the private disciplining of a delinquent soul. Foucault's work is renowned for its original insights, and Discipline and Punish contains several of his most compelling observations. Much of the focus of the book is on making new connections between knowledge and power, leading Foucault to sketch out a new interpretation of the relationship between voir, savoir and pouvoir - or, 'to see is to know is to have power.' Foucault also dwells in fascinating detail on the true implications of a uniquely creative solution to the problems generated by incarcerating large numbers of criminals in a confined space - Jeremy Bentham's 'panopticon,' a prison constructed around a central tower from which hidden guards might - or might not - be monitoring any given prisoner at any given time. As Foucualt points out, the panopticon creates a prison in which inmates will discipline themselves, for fear of punishment, even when there are no guards present. He goes on to apply this insight to the manner in which all of us behave in the outside world - a world in which CCTV and speed cameras are explicitly designed to modify our behavior. Foucault's highly original vision of prisons also ties them to broader structures of power, allowing him to argue that all previous conceptions of prison are misleading, even wrong. For Foucault, the ultimate purpose of incarceration is neither to punish inmates, nor to reduce crime. It is to produce delinquency as a way of enabling the state to control and of structure crime.

Civil society organizations, nonprofits, national and international nongovernmental organizations, and a variety of formal and informal associations have coalesced into a world political force. Though the components of this so-called third sector vary by country, their cumulative effects play an ever-greater role in global affairs. Looking at relief and welfare organizations, innovation organizations, social networks, and many other kinds of groups, Meghan Elizabeth Kallman and Terry Nichols Clark explore the functions, impacts, and composition of the nonprofit sector in six key countries. Chinese organizations, for example, follow the predominantly Asian model of government funding that links their mission to national political goals. Western groups, by contrast, often explicitly challenge government objectives, and even gain relevance and cache by doing so. In addition, Kallman and Clark examine groups in real-world contexts, providing a wealth of political-historical background, in-depth consideration of interactions with state institutions, region-by-region comparisons, and suggestions for how groups can borrow policy options across systems. Insightful and forward-seeing, The Third Sector provides a rare international view of organizations and agendas driving change in today's international affairs.

Simple is rarely easy to implement. However, as a recent Flow trainee puts it, "Flow 'plays nice' with everyone! And, it will enable you to successfully customize and implement whatever solution you choose." Flow is the distillation of over fifty years of successful, hands-on experience that has delivered more than 100 million US dollars in value-add to companies in Europe, the United States, and Asia. Putting Flow into practice, one company increased profit $550,000 in one year on $2.5 million of revenue, and a large Asian telecom turned around a mission critical project from a projected 2-year schedule overrun and 300% budget increase to delivering seven months early and $4 million under the original budget in a 90-day period. Ted and Andrew Kallman unify Traditional management and Agile methodologies enabling successful results, regardless of the existing leadership framework. Simple and easy to understand, Flow helps individuals, teams, and organizations create and sustain high performance.

PL/SQL is the procedural programming language of choice in the Oracle database. It is completely integrated with SQL and is the most fully optimized, highest performance language for database transaction processing. This book is about effective techniques to solve problems using PL/SQL.

This book teaches you all of the core concepts behind using the database, shows you the tools and techniques you need to master, and gives you practical examples of programming Oracle. teaching you Oracle technology. need to use Oracle databases with confidence. Oracle is the world's leading relational database. used properly, is the fastest and most scaleable database on which to build enterprise scale applications. an overnight job. this book have that experience. application or administering the database and can guarantee you that the techniques taught in this book are proven and have led them through many successful implementations.

Peace Corps volunteers seem to exemplify the desire to make the world a better place. Yet despite being one of history's clearest cases of organized idealism, the Peace Corps has, in practice, ended up cultivating very different outcomes among its volunteers. By the time they return from the Peace Corps, volunteers exhibit surprising shifts in their political and professional consciousness. Rather than developing a systemic perspective on development and poverty, they tend instead to focus on individual behavior; they see professions as the only legitimate source of political and social power. They have lost their idealism, and their convictions and beliefs have been reshaped along the way. The Death of Idealism uses the case of the Peace Corps to explain why and how participation in a bureaucratic organization changes people's ideals and politics. Meghan Elizabeth Kallman offers an innovative institutional analysis of the role of idealism in development organizations. She details the combination of social forces and organizational pressures that depoliticizes Peace Corps volunteers, channels their idealism toward professionalization, and leads to cynicism or disengagement. Kallman sheds light on the structural reasons for the persistent failure of development organizations and the consequences for the people involved. Based on interviews with over 140 current and returned Peace Corps volunteers, field observations, and a large-scale survey, this deeply researched, theoretically rigorous book offers a novel perspective on how people lose their idealism, and why that matters.

Peace Corps volunteers seem to exemplify the desire to make the world a better place. Yet despite being one of history's clearest cases of organized idealism, the Peace Corps has, in practice, ended up cultivating very different outcomes among its volunteers. By the time they return from the Peace Corps, volunteers exhibit surprising shifts in their political and professional consciousness. Rather than developing a systemic perspective on development and poverty, they tend instead to focus on individual behavior; they see professions as the only legitimate source of political and social power. They have lost their idealism, and their convictions and beliefs have been reshaped along the way. The Death of Idealism uses the case of the Peace Corps to explain why and how participation in a bureaucratic organization changes people's ideals and politics. Meghan Elizabeth Kallman offers an innovative institutional analysis of the role of idealism in development organizations. She details the combination of social forces and organizational pressures that depoliticizes Peace Corps volunteers, channels their idealism toward professionalization, and leads to cynicism or disengagement. Kallman sheds light on the structural reasons for the persistent failure of development organizations and the consequences for the people involved. Based on interviews with over 140 current and returned Peace Corps volunteers, field observations, and a large-scale survey, this deeply researched, theoretically rigorous book offers a novel perspective on how people lose their idealism, and why that matters.

""I've worked with simulation in business for over 20 years, and Allman really nails it with this book. I admit that I own his previous book on structured finance cash flows, but I was surprised by what I found in here. He addresses the fundamental questions of how decision makers react to simulations and his read was very much in accordance with what I've experienced myself. When it came to the nuts and bolts of describing the different types of simulation analysis the book becomes incredibly detailed. There is working code and models for a fantastic array of the most common simulation problems. If you're so inclined, the book very carefully steps through the tricky math needed to really understand the theory behind stochastic modeling in finance. If you're preparing models that include any kind of randomization or stochastic modeling component, this book is a must-read, a tremendous value and time-saver."" -- David Brode of The Brode Group

A practical guide to understanding and implementing financial simulation modeling

As simulation techniques become more popular among the financial community and a variety of sub-industries, a thorough understanding of theory and implementation is critical for practitioners involved in portfolio management, risk management, pricing, and capital budgeting. "Financial Simulation Modeling in Excel" contains the information you need to make the most informed decisions possible in your professional endeavors.

"Financial Simulation Modeling in Excel" contains a practical, hands-on approach to learning complex financial simulation methodologies using Excel and VBA as a medium. Crafted in an easy to understand format, this book is suitable for anyone with a basic understanding of finance and Excel. Filled with in-depth insights and expert advice, each chapter takes you through the theory behind a simulation topic and the implementation of that same topic in Excel/VBA in a step-by-step manner.Organized in an easy-to-follow fashion, this guide effectively walks you through the process of creating and implementing risk models in ExcelA companion website contains all the Excel models risk experts and quantitative analysts need to practice and confirm their results as they progressKeith Allman is the author of other successful modeling books, including "Corporate Valuation Modeling" and "Modeling Structured Finance Cash Flows with Microsoft Excel"

Created for those with some background in finance and experience in Excel, this reliable resource shows you how to effectively perform sound financial simulation modeling, even if you've yet to do extensive modeling up to this point in your professional or academic career.

Civil society organizations, nonprofits, national and international nongovernmental organizations, and a variety of formal and informal associations have coalesced into a world political force. Though the components of this so-called third sector vary by country, their cumulative effects play an ever-greater role in global affairs. Looking at relief and welfare organizations, innovation organizations, social networks, and many other kinds of groups, Meghan Elizabeth Kallman and Terry Nichols Clark explore the functions, impacts, and composition of the nonprofit sector in six key countries. Chinese organizations, for example, follow the predominantly Asian model of government funding that links their mission to national political goals. Western groups, by contrast, often explicitly challenge government objectives, and even gain relevance and cache by doing so. In addition, Kallman and Clark examine groups in real-world contexts, providing a wealth of political-historical background, in-depth consideration of interactions with state institutions, region-by-region comparisons, and suggestions for how groups can borrow policy options across systems. Insightful and forward-seeing, The Third Sector provides a rare international view of organizations and agendas driving change in today's international affairs.

Michel Foucault is famous as one of the 20th-century’s most innovative thinkers – and his work on Discipline and Punish was so original and offered models so useful to other scholars that the book now ranks among the most influential academic works ever published.

Foucault’s aim is to trace the way in which incarceration was transformed between the seventeenth and twentieth centuries. What started as a spectacle, in which ritual punishments were focused on the prisoner’s body, eventually became a matter of the private disciplining of a delinquent soul.

Foucault’s work is renowned for its original insights, and Discipline and Punish contains several of his most compelling observations. Much of the focus of the book is on making new connections between knowledge and power, leading Foucault to sketch out a new interpretation of the relationship between voir, savoir and pouvoir – or, ‘to see is to know is to have power.’ Foucault also dwells in fascinating detail on the true implications of a uniquely creative solution to the problems generated by incarcerating large numbers of criminals in a confined space – Jeremy Bentham’s ‘panopticon,’ a prison constructed around a central tower from which hidden guards might – or might not – be monitoring any given prisoner at any given time. As Foucualt points out, the panopticon creates a prison in which inmates will discipline themselves, for fear of punishment, even when there are no guards present. He goes on to apply this insight to the manner in which all of us behave in the outside world – a world in which CCTV and speed cameras are explicitly designed to modify our behavior.

Foucault’s highly original vision of prisons also ties them to broader structures of power, allowing him to argue that all previous conceptions of prison are misleading, even wrong. For Foucault, the ultimate purpose of incarceration is neither to punish inmates, nor to reduce crime. It is to produce delinquency as a way of enabling the state to control and of structure crime.

W. H. Auden called opera the "last refuge of the High Style," and considered it the one art in which the grand manner survived the ironic levelings of modernity. He began writing libretti soon after he arrived in America in 1939 and abandoned his earlier attempts to write public, political drama. Opera gave him the opportunity to rise to the high style in public, not in an attempt to elevate his own status as a poet, but in service of the heroic voice of the singers. These works present their mythical actions with a direct intensity unlike anything in even his greatest poems. In this volume of Auden and Chester Kallman's libretti, extensive historical and textual notes trace the history of the production and revision of the works and provide full texts of early scenarios, as well as abandoned and rewritten scenes.

Almost all the works included here were previously published in incomplete and often inaccessible editions--or were never published at all. The book prints for the first time the full text of "Paul Bunyan," Auden's first libretto, which he wrote for music by Benjamin Britten. It also includes Auden and Kallman's "The Rake's Progress," written for Igor Stravinsky, and "Delia," written for Stravinsky but never set to music. The book continues with Auden and Kallman's two libretti written for music by Hans Werner Henze, "Elegy for Young Lovers" and "The Bassarids," and their adaptation of "Love's Labour's Lost," composed by Nicolas Nabokov. It also contains their translation of "The Magic Flute," with its scenes reordered for greater dramatic coherence and added dialogue for sharper mythical significance, and their antimasque, "The Entertainment of the Senses," for music by John Gardner.

The book contains two radio plays--"The Dark Valley," a monologue written by Auden alone, and "The Rocking Horse Winner," written with James Stern and based on a story by D. H. Lawrence. Also included are the unpublished masque that Auden wrote for Kallman's twenty-second birthday, the unpublished versions of "The Dutchess of Malfi" that Auden prepared with Bertolt Brecht, scenarios for a film script and a libretto that were never completed, Auden's narrative for the medieval "Play of Daniel," two narratives for documentary films, and his song lyrics written for "Man of La Mancha" before the producer decided to use a different lyricist.

In Kingdom of God Theodore Kallman illuminates the brief life of a Christian Socialist community founded by four men-a minister, and editor, a professor, and an engineer-on a worn-out cotton plantation just outside of Columbus, Georgia in 1896. While Christian Commonwealth only lasted until 1900, its combination of religious communitarianism and socialist ideology proved attractive to many. It was a place where women enjoyed a sort of political equality and where its school-open to all white students of Muscogee County-emphasized a critique of private property. Kallman explains how particular brand of Tolstoyan anarchism inspired by the Russian novelist's philosophical treatise The Kingdom of God is Within You (1894) and Christ's Sermon on the Mount took root in west-central Georgia and attracted attention from famous onlookers--Leo Tolstoy and Jane Addams included. In Kallman's capable hands, what appears to be merely a blip barely worth mentioning for historians of Georgia and the larger United States, instead emerges as a story that has much to teach us about Gilded Age American and provides necessary context for the surging interest in America's socialist past.

In Kingdom of God Theodore Kallman illuminates the brief life of a Christian Socialist community founded by four men-a minister, and editor, a professor, and an engineer-on a worn-out cotton plantation just outside of Columbus, Georgia in 1896. While Christian Commonwealth only lasted until 1900, its combination of religious communitarianism and socialist ideology proved attractive to many. It was a place where women enjoyed a sort of political equality and where its school-open to all white students of Muscogee County-emphasized a critique of private property. Kallman explains how particular brand of Tolstoyan anarchism inspired by the Russian novelist's philosophical treatise The Kingdom of God is Within You (1894) and Christ's Sermon on the Mount took root in west-central Georgia and attracted attention from famous onlookers--Leo Tolstoy and Jane Addams included. In Kallman's capable hands, what appears to be merely a blip barely worth mentioning for historians of Georgia and the larger United States, instead emerges as a story that has much to teach us about Gilded Age American and provides necessary context for the surging interest in America's socialist past.