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The search for cancer cure from natural products have been
practiced for over a century. For the last 25 years, El-Asmer and
co-workers were pursuing the search for potential therapeutic agent
or new drug models from snake venoms. This work was presented for
partial fulfillment of M.D. in Biochemistry. A cytolytic,
non-antigenic, 8 kDa, glycoprotein (Fraction VIb) was isolated from
crude Naja nigricollis nigricollis spitting cobra venom. This
protein is stable at different pH values and different temperatures
up to 100 C, lethal to mice, with LD50 1.83 mg/kg. Small doses
induced cytolytic effect on hepatocellular carcinoma, colon cancer
and breast cancer cells while larger doses caused hemolysis of red
blood cells. Thus, this protein can be considered a target compound
for further researches as it can be a potential bio-therapeutic
agent for cancer treatment, or a model for new drug design."
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