Cancer glycobiology is a blazing hot area of cancer research with aberrant post-translational glycosylations on lipids and proteins considered critical for cancer development and metastasis. The NIH/NCI Alliance of Glycobiologists for Cancer Research is a consortium of (10) tumor glycobiology laboratories funded to investigate how cancer-associated glycans (CAG) impact the development and metastasis of cancer. The hope of this momentous effort is to discover CAGs for use as novel biomarkers to detect early-stage cancer or its aggressive behavior or, alternatively, as novel molecular targets with the promise of a curative approach to cancer therapy. The mission of the 'Alliance' is to study structure and function of CAGs in cancer development and to provide clinically useful biomarkers for detecting cancer early or the potential of metastasis. This charge has stimulated extensive collaborations across US and International institutions to accelerate discovery of glycan-based biomarkers to the forefront of NCI's efforts to diagnose early-stage cancer and provide curative anti-cancer therapies. The main goals of these research efforts are: 1. To identify and study how cancer-associated glycans functionally impact cancer growth and metastasis 2. To identify cancer-associated glycans that can serve as biomarkers for the detection or progression of cancer 3. To develop cancer-associated glycans as novel therapeutic targets for the treatment and cure of cancer This volume consists of (9) chapters, one from each funded laboratory, that reviews new methods and mechanisms highlighting glycoconjugates and their roles as cancer biomarkers and/or anti-cancer therapeutic targets.

Karen Abbott, the New York Times bestselling author of Sin in the Second City and "pioneer of sizzle history" (USA Today), tells the spellbinding true story of four women who risked everything to become spies during the Civil War.Karen Abbott illuminates one of the most fascinating yet little known aspects of the Civil War: the stories of four courageous women--a socialite, a farmgirl, an abolitionist, and a widow--who were spies.After shooting a Union soldier in her front hall with a pocket pistol, Belle Boyd became a courier and spy for the Confederate army, using her charms to seduce men on both sides. Emma Edmonds cut off her hair and assumed the identity of a man to enlist as a Union private, witnessing the bloodiest battles of the Civil War. The beautiful widow, Rose O'Neale Greenhow, engaged in affairs with powerful Northern politicians to gather intelligence for the Confederacy, and used her young daughter to send information to Southern generals. Elizabeth Van Lew, a wealthy Richmond abolitionist, hid behind her proper Southern manners as she orchestrated a far-reaching espionage ring, right under the noses of suspicious rebel detectives.Using a wealth of primary source material and interviews with the spies' descendants, Abbott seamlessly weaves the adventures of these four heroines throughout the tumultuous years of the war. With a cast of real-life characters including Walt Whitman, Nathaniel Hawthorne, General Stonewall Jackson, detective Allan Pinkerton, Abraham and Mary Todd Lincoln, and Emperor Napoleon III, Liar, Temptress, Soldier, Spy draws you into the war as these daring women lived it.Liar, Temptress, Soldier, Spy contains 39 black & photos and 3 maps.

This is a book about a stage and screen enigma of the past. Gypsy Rose Lee was an early vaudeville, stage and screen star about which little truth has been written. This book provides a more in-depth and factual account of the well-concealed life of a legend.