This volume contains the proceedings of the NATO Advanced Study Institute on "Pictorial Information Systems in Medicine" held August 27-September 7, 1984 in Hotel Maritim, Braunlage/Harz, Federal Republic of Germany. The program committee of the institute consisted of KH Hohne (Director), G. T Herman, G. S. Lodwick, and D. Meyer-Ebrecht. The organization was in the hands of Klaus Assmann and Fritz Bocker In the last decade medical imaging has undergone a rapid development New imaging modalities such as Computer Tomography (CT), Digital Angiography (DSA) and Magnetic Resonance Imaging (MRI) were developed using the capabilities of modern computers. In a modern hospital these technologies produce already more then 25% of image data in digital form. This format lends itself to the design of computer assisted Information systems Integrating data acquisition, presentation, communi cation and archiving for all modalities and users within a department or even a hospital. Advantages such as rapid access to any archived Image, synoptic presentation, computer assisted image analysis to name only a few, are expected. The design of such pictorial information systems, however, often called PACS (Picture Archiving and Communication Systems) In the medical community is a non-trivial task involving know-how from many disciplines such as - Medicine (especially Radiology), - Data Base Technology, - Computer Graphics, - Man Machine Interaction, - Hardware Technology and others. Most of these disCiplines are represented by disjunct scientific communities."

The visualization of human anatomy for diagnostic, therapeutic, and educational pur poses has long been a challenge for scientists and artists. In vivo medical imaging could not be introduced until the discovery of X-rays by Wilhelm Conrad ROntgen in 1895. With the early medical imaging techniques which are still in use today, the three-dimensional reality of the human body can only be visualized in two-dimensional projections or cross-sections. Recently, biomedical engineering and computer science have begun to offer the potential of producing natural three-dimensional views of the human anatomy of living subjects. For a broad application of such technology, many scientific and engineering problems still have to be solved. In order to stimulate progress, the NATO Advanced Research Workshop in Travemiinde, West Germany, from June 25 to 29 was organized. It brought together approximately 50 experts in 3D-medical imaging from allover the world. Among the list of topics image acquisition was addressed first, since its quality decisively influences the quality of the 3D-images. For 3D-image generation - in distinction to 2D imaging - a decision has to be made as to which objects contained in the data set are to be visualized. Therefore special emphasis was laid on methods of object definition. For the final visualization of the segmented objects a large variety of visualization algorithms have been proposed in the past. The meeting assessed these techniques.

This book constitutes the refereed proceedings of the 4th International Conference on Visualization in Biomedical Computing, VBC '96, held in Hamburg, Germany, in September 1996.
The 73 revised full papers presented were selected from a total of 232 submissions. The book reports the state of the art in the field of computer based visualization in medicine and biology. The papers are organized in sections on visualization; image processing; segmentation; registration; brain: description of shape; brain: characterization of pathology; brain: visualization of function; simulation of surgery and endoscopy; image guided surgery and endoscopy.