The most promising method for enhancing solubility, therefore promoting the rate of dissolution is the formation of liquisolid compacts. With Liquisolid technique as described by Spireas liquid formulations such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably flowing and compressible powders, by simple physical blending with selected excipients named the carrier and the coating material. The liquid portion can be a liquid drug, a drug suspension or a drug solution in suitable non-volatile liquid vehicles. Once the carrier is saturated with liquid vehicle, a liquid layer is formed on the particle surface which is instantly adsorbed by the fine coating particles. Hence, an apparently dry, free flowing, and compressible powder is obtained. Generally, various grades of microcrystalline cellulose (MCC) are used as carrier material and various grades of amorphous silicon dioxide (colloidal silica) as coating material.

Out of a special class of writers, Hawthorne, Eliot and Hardy have been deeply influenced by the above ideas and issues. My effort is to interpret and understand on a wider perspective, The Scarlet Letter, Adam Bede and Tess of the D'Urbervilles and the transgression main characters; of their moral accountability for what they do, the quality of the age they lived in, their psyche, their grandeur and their dignity and integrity in suffering and punishment. The three novels are a straightforward portrayal of a scandalous and a grave moral issue that makes the reader think and reflect on the conventions and values that have been part of the foundation of social framework for a long time.

Amlodipine is a long-acting calcium channel blocker used as an antihypertensive and in the treatment of angina pectoris. Like other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and hence reducing blood pressure; in angina, it increases blood flow to the heart muscle. It has poor water solubility, thus exhibiting the problem of variable bioavailability. With Liquisolid technique liquid formulations such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably flowing and compressible powders by simple physical blending with selected excipients named the carrier and the coating material. Liquisolid compacts of poorly water soluble drug Amlodipine Besylate were prepared to enhance its dissolution rate and bioavailability. Liquisolid tablets were prepared using Propylene Glycol (PG) as a non-volatile organic solvent with Avicel PH-101 as carrier and Aerosil as coating material.