Although histopathology remains the gold standard for most immunobullous muco-cutaneous diseases, it must be recognized that not all skin lesions are amenable to definitive specific histologic diagnosis.The histologic diagnosis in turn is used by clinicians to aid in the management of patients. The most accurate diagnosis is the one that most closely correlates with clinical out come & helps to direct the most appropriate clinical intervention. This book aids observers to make appropriate histologic diagnostic findings using immunofluorescence techniques. This book is organized into 4 sections including Introduction, Fluorecscent Microscopy, Immunofluorescence & its techniques, and Immunofluorescence findings in immunobullous diseases like Intra epidermal immunobullous diseases & Sub-epidermal immunobullous diseases.

Increased oxidative stress as a result of excessive production of lipid peroxidation and reactive nitrogen species in association with disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases, most notably oral cancer. Thus, estimation of oxidant antioxidant status in oral squamous cell carcinoma patients could serve as a useful marker in choosing the correct therapy and also to monitor the effectiveness of such therapy and tumor recurrence. Also antioxidant therapy might prove useful in preventing the adverse effects caused by chemotherapy and radiotherapy.As free radicals are considered to be involved in the development of pre-cancer, determination of oxidant-antioxidant status in these patients may be helpful in successful management, thereby arresting it in early stages and avoiding the possible consequences of progression to malignancy.

EVEN THOUGH SALIVA LACKS THE DRAMA OF BLOOD, SINCERITY OF SWEAT, EMOTIONS OF TEARS, SALIVA SHOULD BE USED AS A TUMOR MARKER AS ITS CONSTITUENT SHOWS VARIATION DURING PATHOLOGY FOR VERY EARLY DIAGNOSIS OF CANCER AND ALSO TO CHECK DURING THE FOLLOW UP STAGES.AS THIS IS ECONOMICAL & REPEATED AT CHAIR SIDE WITH VERY MINIMAL LABORATORY EQUIPMENTS.ALSO FEW STUDIES ON THE ORAL CANDIDA ALBICANS HAS SHOWN THEIR MALIGNANT POTENTIAL ALONG WITH LEUKOPLAKIA.HENCE THIS STUDY EMPHASISES ON BOTH MICROBILOGY, BIOCHEMISTRY & ORAL PATHOLOGY.THIS WAS JUST AN SMALL SUCCESSFUL ATTEMPT STILL FURTHER MORE RESEARCH HAS TO BE DONE IN THIS CONTEXT.