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The kidney and liver were removed, preserved and processed for
paraffin sections and hematoxylin and eosin (H&E) staining. The
animals in the control group showed normal histological and
biochemical parameters. Conversely, animals that received
100mg/kgbw of the extract showed slight difference in their hepatic
cyto-architecture while animals that were administered with
200mg/kgbw of the extract revealed distorted morphological feature
showing shrunken sinusoid and dilation of the central vein
suggesting that the extract has adverse effect on the morphology of
the liver. The kidney histology of the animals treated with
100mg/kgbw and 200mg/kgbw of the extract revealed slight edema,
necrosis of tubular cells suggesting possible adverse effect on
renal function. Serum chemistry revealed significantly raised
sodium and decreased potassium levels in animals treated with
100mg/kgbw, but chloride, creatinine and potassium not
significantly affected (P>0.05). Animals treated with 200mg/kgbw
of the extract had significantly raised sodium levels, but reduced
potassium, chloride and creatinine relative to control (P
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