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In the past five years, a surprising and intense resurgence in
interest in vitamins and other micronutrients and their role in
health and dis ease has occurred. The recognition has emerged that
vitamins not only are essential for life .in that severe
nutritional deficiencies occur in their absence, but that these
compounds may also serve as natural inhibitors of cancer. Synthetic
alterations of the basic vitamin A mole cule have also resulted in
the production of compounds that are more potent as anticancer
agents than the natural substance and may have substantial
therapeutic activity as well. Whether other vita mins can be
changed or altered to produce a better anticancer effect than the
native compound has been little explored to date, but should be a
fruitful pursuit for future study. In our concluding remarks to the
First International Conference in 1982, we speculated that rapid
advances in our understanding of vi tamins would occur in the next
few years and that large-scale inter vention trials of vitamins as
preventive agents in defined human pop ulations would be started.
This anticipated generation of data on vitamins and their
interactions has proceeded rapidly and the impor tance of
interactions between vitamins and other micronutrients in the
prevention setting has become better appreciated. Currently, more
than 25 intervention trials with a variety of target populations
using vitamins and other micronutrients have been started, but it
re mains too early for meaningful analysis of the results to date."
During the last 10 years, the role of specific nutrients in cancer
prevention and cancer treatment has been the subject of intense
basic, preclinical, and clinical research. At present, the major
focus of nutri tional oncology is on the mechanisms of
carcinogenesis and their modification by nutrients and on cancer
prevention studies in animals and humans. Some human
epidemiological studies have confirmed the hypothesis, developed on
animals, that there is an inverse relation ship between the intake
and/or level of 3-carotene, vitamin A vita min E, or vitamin C and
the risk of cancer, whereas others have shown no such relationship.
This is not unexpected, since the protective effect of individual
nutrients may be too small to be detected by epidemiological
methodologies in which a single vitamin or mineral is considered as
one variable. Conclusive evidence regarding the role of nutrients
in human cancer prevention will come from a well designed human
intervention study using one or more nutrients in a population that
has a high risk of developing cancer. The involvement of specific
nutrients in the regulation of protooncogene expression has just
begun. Also, some of the results of human intervention trials are
beginning to yield interesting results. A large number of interna
tional scientists from various disciplines, including cell biology,
mo lecular biology, nutritional oncology, epidemiology, and public
health, reviewed and discussed their most recent findings. The
following topics were emphasized: 1. Mechanisms of carcinogenesis;
2."
Nutrients in Cancer Prevention and Treatment contains articles that
were presented by leading researchers and physicians in the field
of nutritional oncology. Most of the previous conference
proceedings on Nutrition and Cancer have dealt primarily with the
issue of the role of nutrients in cancer prevention. This is
logical because enormous quantities of laboratory and epi
demiologic data have been published on the topic. Nutrients in
Cancer Prevention and Treatment also contains several studies on
the role of diet and vitamins in cancer treat ment. There are very
few books that have reviewed laboratory and clinical studies and
the role of vitamins in cancer treatment. There are preliminary
data suggesting that daily supplementa tion with high doses of
certain vitamins in combination with conventional therapeutic
agents may enhance their growth inhibitory effects on tumor cells,
and may protect normal tissues against some of their toxic effects.
This book is unique in the sense that several articles have
discussed the mechanisms of action of individual vitamins on
cellular and molecular parameters. It is very exciting to note that
some of the vitamins inhibit protein kinase C activity, increase
the production of certain growth factors, and modulate the
expression of a number of oncogenes. These studies, at least in
part, offer rationales for the cancer protective effects of
vitamins."
Increased oxidative stress due to the production of excessive
amounts of free radicals along with the effects of chronic
inflammation plays a major role in the initiation and progression
of most chronic diseases. In addition, increased release of
glutamate plays a central role in the pathogenesis of various
disorders. This second edition of Micronutrients in Health and
Disease proposes a novel concept that in order to simultaneously
and optimally reduce oxidative stress, chronic inflammation, and
glutamate, it is essential to increase levels of antioxidant
enzymes as well as levels of dietary and endogenous antioxidant
compounds at the same time. This is accomplished by activating the
Nrf2 pathways and by increasing the levels of antioxidant compounds
and B-vitamins through supplementation. This book proposes a
mixture of micronutrients that achieves this above goal. The
mixture of micronutrients together with modification in diet and
lifestyle may reduce the risk of chronic diseases and in
combination with standard care, may improve the management of these
diseases. KEY FEATURES * Provides evidence in support of the idea
that increased oxidative stress, chronic inflammation, and
glutamate are involved in the pathogenesis of chronic diseases. *
Contains three new chapters on Huntington's disease, Autism
spectra, and Prion disease. * Discusses the role of microRNAs in
the pathogenesis of chronic diseases. * Presents information on
regulation of the expression of microRNAs by reactive oxygen
species and antioxidants. Micronutrients in Health and Disease,
Second Edition serves as a valuable resource for those seeking to
promote healthy aging and prevent and improved management of
chronic diseases.
Increased oxidative stress due to the production of excessive
amounts of free radicals along with the effects of chronic
inflammation plays a major role in the initiation and progression
of most chronic diseases. In addition, increased release of
glutamate plays a central role in the pathogenesis of various
disorders. This second edition of Micronutrients in Health and
Disease proposes a novel concept that in order to simultaneously
and optimally reduce oxidative stress, chronic inflammation, and
glutamate, it is essential to increase levels of antioxidant
enzymes as well as levels of dietary and endogenous antioxidant
compounds at the same time. This is accomplished by activating the
Nrf2 pathways and by increasing the levels of antioxidant compounds
and B-vitamins through supplementation. This book proposes a
mixture of micronutrients that achieves this above goal. The
mixture of micronutrients together with modification in diet and
lifestyle may reduce the risk of chronic diseases and in
combination with standard care, may improve the management of these
diseases. KEY FEATURES * Provides evidence in support of the idea
that increased oxidative stress, chronic inflammation, and
glutamate are involved in the pathogenesis of chronic diseases. *
Contains three new chapters on Huntington's disease, Autism
spectra, and Prion disease. * Discusses the role of microRNAs in
the pathogenesis of chronic diseases. * Presents information on
regulation of the expression of microRNAs by reactive oxygen
species and antioxidants. Micronutrients in Health and Disease,
Second Edition serves as a valuable resource for those seeking to
promote healthy aging and prevent and improved management of
chronic diseases.
The book proposes that a preparation of antioxidants and
micronutrients, in combination with standard therapy, may reduce
progression and improve management better than standard therapy
alone for Alzheimer's, Parkinson's, and Huntington's disease, as
well as PTSD, traumatic brain injury, concussions, and cerebral
vascular insufficiency. The book presents the latest research on
the effects of micronutrients and recommends formulations for use
in combination with standard therapies for these neurodegenerative
diseases and conditions.
Neurological diseases such as Alzhemier s and Parkinson s are
caused by gene defects and are often induced by external agents.
Treatments based on micronutrient formulas show promise, as they
are non-invasive, non-toxic, and inexpensive, and many are
currently being explored in clinical trials. This book presents the
latest research on the effects of micronutrients in the prevention
and treatment of neurodegenerative disorders. Chapters cover the
etiology and management of diseases using micronutrients and their
applications in treating such conditions as Alzheimer s, Parkinson
s, posttraumatic stress disorder, traumatic brain injury,
concussive injury, cerebrovascular insufficiency, and Huntington s
disease. "
This handbook presents the most current information on the effects
of ionizing radiation on mammalian cells, with emphasis on human
tissues. The dose-effect relationship is emphasized in a
quantitative manner. The book contains up-to-date data on the late
effects of low levels of radiation on humans. It also provides some
of the late consequences of radiation therapy detected among cancer
survivors.
Nutrients in Cancer Prevention and Treatment contains articles that
were presented by leading researchers and physicians in the field
of nutritional oncology. Most of the previous conference
proceedings on Nutrition and Cancer have dealt primarily with the
issue of the role of nutrients in cancer prevention. This is
logical because enormous quantities of laboratory and epi
demiologic data have been published on the topic. Nutrients in
Cancer Prevention and Treatment also contains several studies on
the role of diet and vitamins in cancer treat ment. There are very
few books that have reviewed laboratory and clinical studies and
the role of vitamins in cancer treatment. There are preliminary
data suggesting that daily supplementa tion with high doses of
certain vitamins in combination with conventional therapeutic
agents may enhance their growth inhibitory effects on tumor cells,
and may protect normal tissues against some of their toxic effects.
This book is unique in the sense that several articles have
discussed the mechanisms of action of individual vitamins on
cellular and molecular parameters. It is very exciting to note that
some of the vitamins inhibit protein kinase C activity, increase
the production of certain growth factors, and modulate the
expression of a number of oncogenes. These studies, at least in
part, offer rationales for the cancer protective effects of
vitamins.
In the past five years, a surprising and intense resurgence in
interest in vitamins and other micronutrients and their role in
health and dis ease has occurred. The recognition has emerged that
vitamins not only are essential for life .in that severe
nutritional deficiencies occur in their absence, but that these
compounds may also serve as natural inhibitors of cancer. Synthetic
alterations of the basic vitamin A mole cule have also resulted in
the production of compounds that are more potent as anticancer
agents than the natural substance and may have substantial
therapeutic activity as well. Whether other vita mins can be
changed or altered to produce a better anticancer effect than the
native compound has been little explored to date, but should be a
fruitful pursuit for future study. In our concluding remarks to the
First International Conference in 1982, we speculated that rapid
advances in our understanding of vi tamins would occur in the next
few years and that large-scale inter vention trials of vitamins as
preventive agents in defined human pop ulations would be started.
This anticipated generation of data on vitamins and their
interactions has proceeded rapidly and the impor tance of
interactions between vitamins and other micronutrients in the
prevention setting has become better appreciated. Currently, more
than 25 intervention trials with a variety of target populations
using vitamins and other micronutrients have been started, but it
re mains too early for meaningful analysis of the results to date."
During the last 10 years, the role of specific nutrients in cancer
prevention and cancer treatment has been the subject of intense
basic, preclinical, and clinical research. At present, the major
focus of nutri tional oncology is on the mechanisms of
carcinogenesis and their modification by nutrients and on cancer
prevention studies in animals and humans. Some human
epidemiological studies have confirmed the hypothesis, developed on
animals, that there is an inverse relation ship between the intake
and/or level of !3-carotene, vitamin A vita min E, or vitamin C and
the risk of cancer, whereas others have shown no such relationship.
This is not unexpected, since the protective effect of individual
nutrients may be too small to be detected by epidemiological
methodologies in which a single vitamin or mineral is considered as
one variable. Conclusive evidence regarding the role of nutrients
in human cancer prevention will come from a well designed human
intervention study using one or more nutrients in a population that
has a high risk of developing cancer. The involvement of specific
nutrients in the regulation of protooncogene expression has just
begun. Also, some of the results of human intervention trials are
beginning to yield interesting results. A large number of interna
tional scientists from various disciplines, including cell biology,
mo lecular biology, nutritional oncology, epidemiology, and public
health, reviewed and discussed their most recent findings. The
following topics were emphasized: 1. Mechanisms of carcinogenesis;
2.
In this practical scientific guide, Kedar N. Prasad, Ph.D. reveals
the latest revolutionary discoveries on the use of antioxidants to
treat Parkinson's and Huntington's disease. He details how the
proper combinations of vitamin and antioxidant supplements, along
with polyphenic compounds such as curcumin and resveratrol, can
greatly increase the effectiveness of standard medical treatments
for these diseases, slowing the progression of symptoms as well as
delaying onset despite family history. He provides an
easy-to-follow daily supplement regimen to target free-radical
damage and inflammation and slow the progression of these diseases.
Offering a safe self-help complement to standard medications, this
guide provides a truly holistic approach to the prevention and
treatment of both Parkinson's and Huntington's disease.
In this practical yet scientific guide, leading researcher in
cancer, heart disease, and diabetes prevention Kedar N. Prasad,
Ph.D., reveals the latest revolutionary discoveries on the use of
antioxidants and micronutrients to treat diabetes. He details how
the proper combinations of vitamin and antioxidant supplements can
greatly increase the effectiveness of standard medical treatments
to halt and even reverse the progression of both type I and type II
diabetes and prevent onset in those who are diagnosed as
prediabetic. Prasad shows how chronic inflammation, oxidative
stress, and free radical damage are the chief culprits for the
progression of diabetes and its complications and that merely
changing your diet and activity level and regulating blood glucose
levels cannot fully counteract this unhealthy internal state. He
provides an easy-to-follow daily supplement regime for both
diabetics and prediabetics in multiple age groups to target free
radical damage and cell injury and stop the progression of diabetes
complications. Reviewing much of the scientific research on
diabetes treatment, he debunks the flawed conclusions of the
medical community that vitamins and antioxidants are ineffective,
revealing how the studies focused on specific micronutrients rather
than synergistic combinations. Offering the missing complement to
the standard care of diet, exercise, and lifestyle changes promoted
by mainstream medicine, this guide provides a truly holistic
approach to diabetes prevention, treatment, and care.
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