Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. This book describes various ways of approaching and interpreting the data produced by clinical trial studies, with a special emphasis on the essential role that biostatistics plays in clinical trials. The book includes 18 carefully reviewed chapters on recent developments in clinical trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches.

Since Charles Spearman published his seminal paper on factor analysis in 1904 and Karl Joresk ] og replaced the observed variables in an econometric structural equation model by latent factors in 1970, causal modelling by means of latent variables has become the standard in the social and behavioural sciences. Indeed, the central va- ables that social and behavioural theories deal with, can hardly ever be identi?ed as observed variables. Statistical modelling has to take account of measurement - rors and invalidities in the observed variables and so address the underlying latent variables. Moreover, during the past decades it has been widely agreed on that serious causal modelling should be based on longitudinal data. It is especially in the ?eld of longitudinal research and analysis, including panel research, that progress has been made in recent years. Many comprehensive panel data sets as, for example, on human development and voting behaviour have become available for analysis. The number of publications based on longitudinal data has increased immensely. Papers with causal claims based on cross-sectional data only experience rejection just for that reason."

After Karl JAreskog's first presentation in 1970, Structural Equation Modelling or SEM has become a main statistical tool in many fields of science. It is the standard approach of factor analytic and causal modelling in such diverse fields as sociology, education, psychology, economics, management and medical sciences. In addition to an extension of its application area, Structural Equation Modelling also features a continual renewal and extension of its theoretical background. The sixteen contributions to this book, written by experts from many countries, present important new developments and interesting applications in Structural Equation Modelling. The book addresses methodologists and statisticians professionally dealing with Structural Equation Modelling to enhance their knowledge of the type of models covered and the technical problems involved in their formulation. In addition, the book offers applied researchers new ideas about the use of Structural Equation Modeling in solving their problems. Finally, methodologists, mathematicians and applied researchers alike are addressed, who simply want to update their knowledge of recent approaches in data analysis and mathematical modelling.

This unique book provides an overview of continuous time modeling in the behavioral and related sciences. It argues that the use of discrete time models for processes that are in fact evolving in continuous time produces problems that make their application in practice highly questionable. One main issue is the dependence of discrete time parameter estimates on the chosen time interval, which leads to incomparability of results across different observation intervals. Continuous time modeling by means of differential equations offers a powerful approach for studying dynamic phenomena, yet the use of this approach in the behavioral and related sciences such as psychology, sociology, economics and medicine, is still rare. This is unfortunate, because in these fields often only a few discrete time (sampled) observations are available for analysis (e.g., daily, weekly, yearly, etc.). However, as emphasized by Rex Bergstrom, the pioneer of continuous-time modeling in econometrics, neither human beings nor the economy cease to exist in between observations. In 16 chapters, the book addresses a vast range of topics in continuous time modeling, from approaches that closely mimic traditional linear discrete time models to highly nonlinear state space modeling techniques. Each chapter describes the type of research questions and data that the approach is most suitable for, provides detailed statistical explanations of the models, and includes one or more applied examples. To allow readers to implement the various techniques directly, accompanying computer code is made available online. The book is intended as a reference work for students and scientists working with longitudinal data who have a Master's- or early PhD-level knowledge of statistics.

This new volume reviews longitudinal models and analysis procedures for use in the behavioral and social sciences. Written by distinguished experts in the field, the book presents the most current approaches and theories, and the technical problems that may be encountered along the way. Readers will find new ideas about the use of longitudinal analysis in solving problems that arise due to the specific nature of the research design and the data available. Divided into two parts, Longitudinal Models in the Behavioral and Related Sciences opens with the latest theoretical developments. In particular, the book addresses situations that arise due to the categorical nature of the data, issues related to state space modeling, and potential problems that may arise from network analysis and/or growth-curve data. The focus of part two is on the application of longitudinal modeling in a variety of disciplines. The book features applications such as heterogeneity on the patterns of a firm's profit, on house prices, and on delinquent behavior; non-linearity in growth in assessing cognitive aging; measurement error issues in longitudinal research; and distance association for the analysis of change. Part two clearly demonstrates the caution that should be taken when applying longitudinal modeling as well as in the interpretation of the results. Longitudinal Models in the Behavioral and Related Sciences is ideal for advanced students and researchers in psychology, sociology, education, economics, management, medicine, and neuroscience.

This unique book provides an overview of continuous time modeling in the behavioral and related sciences. It argues that the use of discrete time models for processes that are in fact evolving in continuous time produces problems that make their application in practice highly questionable. One main issue is the dependence of discrete time parameter estimates on the chosen time interval, which leads to incomparability of results across different observation intervals. Continuous time modeling by means of differential equations offers a powerful approach for studying dynamic phenomena, yet the use of this approach in the behavioral and related sciences such as psychology, sociology, economics and medicine, is still rare. This is unfortunate, because in these fields often only a few discrete time (sampled) observations are available for analysis (e.g., daily, weekly, yearly, etc.). However, as emphasized by Rex Bergstrom, the pioneer of continuous-time modeling in econometrics, neither human beings nor the economy cease to exist in between observations. In 16 chapters, the book addresses a vast range of topics in continuous time modeling, from approaches that closely mimic traditional linear discrete time models to highly nonlinear state space modeling techniques. Each chapter describes the type of research questions and data that the approach is most suitable for, provides detailed statistical explanations of the models, and includes one or more applied examples. To allow readers to implement the various techniques directly, accompanying computer code is made available online. The book is intended as a reference work for students and scientists working with longitudinal data who have a Master's- or early PhD-level knowledge of statistics.

Since Charles Spearman published his seminal paper on factor analysis in 1904 and Karl Joresk og replaced the observed variables in an econometric structural equation model by latent factors in 1970, causal modelling by means of latent variables has become the standard in the social and behavioural sciences. Indeed, the central va- ables that social and behavioural theories deal with, can hardly ever be identi?ed as observed variables. Statistical modelling has to take account of measurement - rors and invalidities in the observed variables and so address the underlying latent variables. Moreover, during the past decades it has been widely agreed on that serious causal modelling should be based on longitudinal data. It is especially in the ?eld of longitudinal research and analysis, including panel research, that progress has been made in recent years. Many comprehensive panel data sets as, for example, on human development and voting behaviour have become available for analysis. The number of publications based on longitudinal data has increased immensely. Papers with causal claims based on cross-sectional data only experience rejection just for that reason.

After Karl Joreskog's first presentation in 1970, Structural Equation Modelling or SEM has become a main statistical tool in many fields of science. It is the standard approach of factor analytic and causal modelling in such diverse fields as sociology, education, psychology, economics, management and medical sciences. In addition to an extension of its application area, Structural Equation Modelling also features a continual renewal and extension of its theoretical background. The sixteen contributions to this book, written by experts from many countries, present important new developments and interesting applications in Structural Equation Modelling. The book addresses methodologists and statisticians professionally dealing with Structural Equation Modelling to enhance their knowledge of the type of models covered and the technical problems involved in their formulation. In addition, the book offers applied researchers new ideas about the use of Structural Equation Modeling in solving their problems. Finally, methodologists, mathematicians and applied researchers alike are addressed, who simply want to update their knowledge of recent approaches in data analysis and mathematical modelling."

This new volume reviews longitudinal models and analysis procedures for use in the behavioral and social sciences. Written by distinguished experts in the field, the book presents the most current approaches and theories, and the technical problems that may be encountered along the way. Readers will find new ideas about the use of longitudinal analysis in solving problems that arise due to the specific nature of the research design and the data available. Divided into two parts, Longitudinal Models in the Behavioral and Related Sciences opens with the latest theoretical developments. In particular, the book addresses situations that arise due to the categorical nature of the data, issues related to state space modeling, and potential problems that may arise from network analysis and/or growth-curve data. The focus of part two is on the application of longitudinal modeling in a variety of disciplines. The book features applications such as heterogeneity on the patterns of a firm's profit, on house prices, and on delinquent behavior; non-linearity in growth in assessing cognitive aging; measurement error issues in longitudinal research; and distance association for the analysis of change. Part two clearly demonstrates the caution that should be taken when applying longitudinal modeling as well as in the interpretation of the results. Longitudinal Models in the Behavioral and Related Sciences is ideal for advanced students and researchers in psychology, sociology, education, economics, management, medicine, and neuroscience.