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Containing 350 illustrations, tables, and equations and covering
AAPS/FDA guidelines for the experimentation and analysis of in vivo
and in vitro percutaneous absorption, this reference provides
comprehensive coverage of the development, preparation, and
application of topical and transdermal therapeutic systems.
Recognized international experts discuss the bioequivalence of
dermatological and transdermal dosage forms. They explore the
biochemistry and treatment of skin diseases, the structure and
function of the skin, adverse dermal responses to drug
formulations, mechanisms of drug transport through barrier
membranes, and methods for measuring and modulating percutaneous
permeation.
Contains current American Association of Pharmaceutical
Scientists/Food and Drug Administration (AAPS/FDA) guidelines for
the experimentation and analysis of in vivo and in vitro
percutaneous absorption This up-to-the-minute reference provides
comprehensive coverage of the latest advances in the development,
preparation, and application of topical and transdermal therapeutic
systems-exploring the biochemistry and treatment of various skin
diseases as well as the structure and function of the skin, adverse
dermal responses to drug formulations, mechanisms of drug transport
through barrier membranes, and methods for measuring and modulating
percutaneous permeation. Offers contemporary discussions on the
bioequivalence of dermatological and transdermal dosage forms With
more than 1800 useful references and 350 illustrations, tables, and
equations, Dermatological and Transdermal Formulations is an
essential source for cosmetic and pharmaceutical scientists,
dermatologists, toxicologists, agrochemists, regulatory agency
personnel, and upper-level undergraduate and graduate students in
these disciplines.
Recent advances in our understanding of the development and
morphology of normal skin have led to improved methods to deliver
therapeutic compounds to selected targeted areas both within the
skin and systemically. This reference provides a clear overview of
pharmaceutical and cosmetic practices, drugs, and therapies to
manage and treat major and minor skin disorders. Written for
scientists interested in dermatological therapy and marketers of
pharmaceutical and cosmetic products, the text is also useful for
students developing strong research methods. The book covers drugs
used to manage a range of skin disorders and the site where the
effect is sought. It examines the efficiency and delivery of
topical therapies, including various pharmaceutical therapies. It
also explains how percutaneous absorption is affected by age, skin,
site, race, skin disease, and damage and product form. Particular
emphasis is on novel treatment approaches for major skin diseases
and injuries pertaining to wounds and burns.
This is a 2 volume set. Volume 1 is Dermatological and
Cosmeceutical Development: Absorption Efficacy and Toxicity. Recent
advances in our understanding of the development and morphology of
normal skin has led to improved methods to deliver therapeutic
compounds to selected targeted areas both within the skin and
systemically. This reference provides a clear overview of current
pharmaceutical and cosmetic practices in the management of both
major and minor skin disorders, and provides an expansive overview
of novel drugs and therapies used to treat these conditions.
Written for scientists interested in dermatological therapy and
those concerned with the marketing for pharmaceutical and cosmetic
products, this text will also prove useful for students developing
strong research methods. Volume 2 is Dermal Absorption and Toxicity
Assessment, Second Edition The book Dermal Absorption and Toxicity
Assessment supplies a state-of-the-art overview of the dermal
absorption process, and is divided into six well organized
sections. Written by internationally recognized experts in the
field, this Second Edition is a complete revised and updated text,
covering the wide range of methods used to assess skin absorption
and the various governmental and industrial programs concerned with
skin permeation and toxicity. These include alternative in silico,
in vitro, and in vivo strategies to conduct studies for regulatory
requirements. To make room for this new expanded content, the
editors are publishing a concurrent text entitled: Dermatological
and Cosmetic Development with a concentration on subjects concerned
with dermatological and cosmetic therapies. Dermal Absorption and
Toxicity and Assessment is a completely revised and updated text
expanded to include coverage pertaining to innovative
research...expands on the specific barrier properties of the skin
such as its physical structure, biosensor properties, cutaneous
metabolism, skin lipid morphology, and dermal blood and lymphatic
flow, examines both the standard established laboratory techniques,
for example, diffusion cell technology, and also covers new
techniques like cultured skin equivalents, dermal absorption, and
risk assessment
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