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ATP Binding Cassette (ABC) transporters are a family of integral
membrane proteins that are likely to be represented in all the
cells of all species of archaea, eubacteria and eukaryota. The vast
majority of these proteins control the transport of molecules (from
small hydrophilic ions to lipids and proteins) across cellular
membranes. The human genome encodes 48 ABC transporters and most
have been shown to underlie one or more human diseases. This book -
that brings together state-of-the-art knowledge on proteins in one
volume - will provide students, professors and medical
professionals with a background to the human ABC transporters that
are known to be relevant to diseases. Each of the 14 chapters is
written by a leading researcher in the field and includes
contributions from Joe Bryan and Lydia Aguilar-Bryan, Kazu Ueda,
Jack Riordan and Robert Tamp . The genetics, structure and function
of the proteins, and the future direction of research including the
implications for human health are discussed in depth.
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