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Circadian rhythm sleep disorders are caused by a mismatch between
the sleep - wake pattern and circadian phase. Sleep at the
circadian high is impaired, while alertness is reduced during
wakefulness. This issue discusses biological timekeeping,
consequences of circadian disruption in animal models, influence of
circadian system on disease severity, effect of light on circadian
physiology, melatonin, non-24-hour disorder, irregular sleep-wake
disorder, advanced sleep phase, delayed sleep phase, jet lag, shift
work, circadian disruption and psychiatric disorders, and winter
depression.
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