|
Showing 1 - 3 of
3 matches in All Departments
Protein-tyrosine kinases (PTKs) play an essential role in the
intracellular mitogenic signaling mechanism. In fact, many growth
factor receptors themselves have intrinsic PTK activity, as
evidenced by the cases of epidermal growth factor (EGF), nerve
growth factor (NGF) and stem cell factor (SCF) receptors. In
contrast to these receptor-type PTKs, many PTKs do not have a
transmembrane domain in their structure. These are designated as
non-receptor-type PTKs or cytoplasmic PTKs. Non-receptor PTKs can
be further subdivided into a number of sub- families, one of which
is the Tec family. The Tec family consists of five members, namely
Tec, Btk, Itk/Emt/Tsk, Bmx and Txk/Rlk. Many members of this family
are abundantly expressed in hematopoietic tissues, where they are
presumed to function in the growth, differentiation or both
processes of blood cells. This hypothesis is strengthened by the
fact that the Btk kinase molecule is responsible for X
chromosome-linked agammaglobulinemia (XLA) in humans and X
chromosome-linked immunodeficiency (Xid) in mice.
Accurate interpretation of the organic acid chromatographs obtained
from the gas chromatography/mass spectrometry requires a
significant amount of practice. Pattern recognition is an important
factor and a skill that is gained through time and effort. A Quick
Guide to Metabolic Disease Testing Interpretation, Second Edition,
provides these example chromatographs demonstrating specific
disease-related metabolites for the inborn error of metabolism
diagnosed via this method. One or more representative
chromatographs from each of the common disorders is presented, with
the important compounds noted on the chromatographs. This is a
must-have for laboratory and medical professionals who interpret
testing for the diagnosis and monitoring of IEM.
|
You may like...
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.