Three years on from the previous blockbuster, Marvel comic book character Spider-Man returns in his latest adventure. Peter Parker (Tobey Maguire) and his girl Mary-Jane (Kirsten Dunst) are on the cusp of contentment - but not for long. His ex-friend Harry (James Franco), son of the Green Goblin of the first film, becomes the New Goblin in his desire for revenge against Spider-Man. Fugitive Flint Marko (Thomas Haden Church), killer of Peter's Uncle Ben, has been transformed into the shape-shifting Sandman, possibly Spider-Man's toughest foe so far. To complicate matters further, a parasitic alien symbiote has attached itself to Peter's suit, giving him even greater powers but also bringing out the evil side of his personality. He has to struggle not only against two major adversaries but also against himself.

Viggo Mortensen, Kirsten Dunst and Oscar Isaac star in this thriller adapted from Patricia Highsmith's novel by Hossein Amini, who makes his directorial debut.

In 1962 wealthy married couple Chester and Colette MacFarland (Mortensen and Dunst) are in the Acropolis of Athens, Greece, when they meet shady tour guide Rydal (Isaac). Rydal is immediately taken with the beautiful Colette and doesn't hestitate when the couple invite him to dine with them. Later in the evening, however, he begins to realise that Chester is hiding a dark secret and soon finds himself embroiled in murder.

Rydal helps the MacFarlands evade the authorities but his feelings for Colette cause tension between him and Chester, making the already precarious situation even more dangerous.