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Herpes viruses are widely distributed in nature, causing disease in
organisms as diverse as bivalves and primates, including humans.
Each virus appears to have established a long-standing relationship
with its host, and the viruses have the ability to manipulate and
control the metabolism of host cells, as well as innate and
adaptive antiviral immune responses. Herpes viruses maintain
themselves within hosts in a latent state resulting in virus
persistence for years - usually for the life span of the hosts.
Herpes viruses comprise a large number of pathogens with diverse
cellular targets and biological consequences of infection. What
they have in common is their structure and the fact that they
establish a dormant (latent) infection in their hosts that usually
persists for life. The reviews here will highlight the general
principles of herpes virus infection, with equal attention to
overall principle and important difference. Also, the cell type-
and life-style dependent differences in the establishment and
maintenance of virus persistence will be covered.
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