This book constitutes selected papers from the 19th European, Mediterranean, and Middle Eastern Conference, EMCIS 2022, which was held virtually during December 7-8, 2022.EMCIS covers technical, organizational, business, and social issues in the application of information technology and is dedicated to the definition and establishment of Information Systems (IS) as a discipline of high impact for IS professionals and practitioners. It focuses on approaches that facilitate the identification of innovative research of significant relevance to the IS discipline following sound research methodologies that lead to results of measurable impact. The 47 papers presented in this volume were carefully reviewed and selected from a total of 136 submissions. They were organized in topical sections named: Artificial intelligence; big data and analytics; blockchain technology and applications; cloud computing; digital governance; digital services and social media; emerging computing technologies and trends for business process management; enterprise systems; information system security and information privacy protection; innovative research projects; IT governance and alignment; management and organizational issues in information systems; and metaverse.