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The control of brain edema is still one of the major problems in
surgical and conservative treatment of various cerebral lesions.
Many attempts have been made to develop methods for reducing the
high mortality associated with brain edema. Mter many years of
using hypertonic solutions it can be stated that this type of
therapy has not yielded satisfactory results. During recent years
increasing evidence has been accumulated on the efficacy of
steroids on brain edema. Steroids were reported to result in rapid
relief of signs and symptoms of increased intracranial pressure and
neurological dysfunction accompanying cerebral edema. It was the
aim of this workshop to evaluate the effect of corticosteroids on
brain edema as an advance in therapy. It was hoped that this could
be achieved by a multi disciplinary approach. Though, the volume
contains the contributions of various experts - internists,
neurochemists, neurologists, neuropathologists, neurosurgeons,
pharmacologists, physiologists - who have added considerable
experimental and clin ical evidence on the action of steroids on
brain edema. New pathophysiological aspects regarding the
mechanisms underlying the formation and resolution of brain The
effectiveness of corticosteroid therapy in various forms edema are
presented. of clinical and experimental brain edema, e. g.
accompanying brain tumors, head injury, spinal cord injury,
cerebrovascular lesions, etc. as well as dosage and duration of
treatment are critically discussed.
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