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In the present work, processes of cell proliferation, cell death,
neurogenesis, and gliogenesis in the mouse hippocampus were
studied. The mapping of distribution of hippocampal mitoses and
counting of their number allowed a more precise definition of the
data concerning the disposition and age reduction of proliferative
sites in Ammon's horn and the dentate gyrus in the mouse. As a
result, the following generalized scheme of development and age
reduction of the germinal zones in the mouse hippocampus has been
suggested. 1. Ammon's horn a) The ventricular zone, from the
beginning of formation of the hippocampus (Ell) until E20 b) The
suprafimbrial zone, from El6 until P7 2. Dentate gyrus a) The prime
germinal zone ("the anlage of the dentate gyrus" of Stanfield and
CowanI979b), from E15 until P3 b) The proliferative zone of the
hilus, from P3 until Pl4 c) The subgranular zone, from P3 until
adult age The adduced scheme needs some comments: 1. In the
hippocampus (as well as in other formations of the developing
brain), primary precursors of all types of cells of neuroectodermal
origin are represented by cells of the ventricular zone. They give
rise to cells of secondary germinal zones in the dentate gyrus and
Ammon's horn and are direct precursors of the majority (if not of
all) neuronal cells in Ammon's horn, the earliest originating
generations of neurons in the dentate gyrus, hippocampal radial
glial cells, and, evidently, of a considerable part of astroblasts
and oligodendroblasts in Ammon's horn.
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