|
Showing 1 - 3 of
3 matches in All Departments
This volume contains the proceedings of the EMBO-NATO-CEC Advanced
Research Workshop on "Guanine-nucleotide binding proteins. Common
structural and functional properties," which was held in Renesse,
The Netherlands, August 6-11, 1988. The transmission of information
is one of the most important processes in cellular life and
involves the most diverse physiological functions. The cellular
membrane, as the obligatory target for external signals, harbours
complex pathways transducing the signals from the receptors of the
external stimuli to the cytoplasmic effector. Heterotrimeric
proteins are fundamental components of these pathways. Other
proteins that are monomeric may be found associated with the
membrane or in soluble form in the cytoplasm, and' can also
function in signal transduction. Intracellular transmission of
signals may proceed in an analogous fashion, protein synthesis
being a well-known example. It is one of the most remarkable and
puzzling observations of recent years that all of these proteins
share common properties, both functionally and structurally. The ir
primary structures show pronounced s imilari ties, in most cases
concentrated in the NH2-terminal portion of the molecule. They all
bind guanine nucleotides (hence the general name of G-proteins) and
are GTPases, a crucial enzymatic activity, since it converts the
active complex induced by GTP into the inactive one induced by GDP.
Consensus sequences have been ident if ied as responsable for
interact ing with the different parts of the guanine nucleotide.
Additional Contributing Authors Include Philip Siekevitz, Fritz
Lipmann, Harold M. Bates And Others.
Additional Contributing Authors Include Philip Siekevitz, Fritz
Lipmann, Harold M. Bates And Others.
|
|