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A probable neurobiological role for the trace amines began to
emerge as soon as techniques sufficiently sophisticated to detect
them were developed. Techniques for quantitative analyses included
radioenzymatic procedures and, more recently, HPlC-EC and auto
mated GC-MS. The methods are applied after separation of the sub
stances to be analyzed and after their purification by
physicochemical procedures that are becoming more and more
efficient. The identification and quantitative analysis of minute
amounts of trace amines in biological fluids or tissues is in
itself a remarkable technological achievement. The enormous task
that several teams of research workers have set themselves is to
investigate the origin of the trace amines, to understand their
metabolism, and to discover whether or not they possess an
important biological role. The 2nd Trace Amines Symposium at
Weitenburg Castle near Tubingen from the 15th to the 19th May 1985
was held to gain a somewhat clearer insight into the present state
of knowledge. Since the first meeting in 1983 our knowledge has
increased and interest is deepening. Hence the idea proposed at
that first meeting, of organizing similar gather ings at regular
intervals, has come to fruition. Covered in the
Neuropsychopharmacology section of this book are studiesof the
effects of certain trace amines on different forms of be havior, on
neurotransmission mediated by . the classical neuro transmitters,
on their biosynthesis or on catabolism, on their possible
occurrence as a result of alternative metabolic pathways for the
amino acids, and in some instances their neuroanatomical
distributions."
A probable neurobiological role for the trace amines began to
emerge as soon as techniques sufficiently sophisticated to detect
them were developed. Techniques for quantitative analyses included
radioenzymatic procedures and, more recently, HPlC-EC and auto
mated GC-MS. The methods are applied after separation of the sub
stances to be analyzed and after their purification by
physicochemical procedures that are becoming more and more
efficient. The identification and quantitative analysis of minute
amounts of trace amines in biological fluids or tissues is in
itself a remarkable technological achievement. The enormous task
that several teams of research workers have set themselves is to
investigate the origin of the trace amines, to understand their
metabolism, and to discover whether or not they possess an
important biological role. The 2nd Trace Amines Symposium at
Weitenburg Castle near Tubingen from the 15th to the 19th May 1985
was held to gain a somewhat clearer insight into the present state
of knowledge. Since the first meeting in 1983 our knowledge has
increased and interest is deepening. Hence the idea proposed at
that first meeting, of organizing similar gather ings at regular
intervals, has come to fruition. Covered in the
Neuropsychopharmacology section of this book are studiesof the
effects of certain trace amines on different forms of be havior, on
neurotransmission mediated by . the classical neuro transmitters,
on their biosynthesis or on catabolism, on their possible
occurrence as a result of alternative metabolic pathways for the
amino acids, and in some instances their neuroanatomical
distributions."
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