Where can you eat dinner under the sea? Which country has the most pyramids? Can a church become a swimming pool? Including a stunning central gatefold map that opens out to reveal where all 80 structures are located, this book is a visual celebration of the incredible structures people have built throughout history and their cultural significance. From ancient wonders such as Stonehenge to bridges spanning countries, record breaking rollercoasters and hotels where even the beds are made of ice. Discover a floating palace, a terracotta army, a cinema in a bank vault, and a building so tall that clouds form at the top!

This year notes two major changes in the annual Detroit Cancer Symposium. The first is our intention of selecting top ics of broad interest to the cancer community and examining the subject from both a basic laboratory and clinical viewpoint. In this way, the importance of both elements of cancer research are noted and the interplay between them emphasized. Further, we believe that Symposia such as this act to stimulate the basic scientist and clinician to continue their studies with the know ledge of the impact that each has upon the other and the nec essary cooperation required to solve the cancer problem. The second change is the publication of this Symposium. The pre vious sixteen were not committed to manuscript form. Given the change in format and intent of the series, we believe that this and subsequent volumes will make important contributions to the cancer literature. The topic of "Biology and Therapy of Acute Leukemia" was chosen for the first Symposium because of its historical signif icance in cancer chemotherapy. The therapeutic rationale for human leukemia is the result of understanding the basic tumor biology largely derived from transplantable leukemias in exper imental animals. It is through these models, as discussed by Dr. Fred Valeriote, that we learned the cellular kinetics of leukemia, the antileukemic effects of new agents and the ef fect of growth perturbation by various chemotherapeutic agents and their combinations.

There have been significant advances in the treatment of sarcomas in the past several years. Further, different clini cal treatment programs are being advocated in different areas including surgery alone, surgery with preoperative or post operative chemotherapy, surgery with different radiotherapy modalities, with each investigator espousing his own treat ment program. On the other side, there is the question of whether these treatment programs are offering better results or whether the natural history of sarcomas has changed. The International Symposium on Sarcomas was held at Innisbrook Resort, Tarpon Springs, Florida, October 8-10, 1987. This was the first international symposium to date involving all of the disciplines treating sarcomas including pathologists, orthopaedic surgeons, general surgeons, medical oncologists, pediatric oncologists, and radiation oncol ogists. The Symposium brought together a number of special ists working in the clinical field of sarcomas for a presen tation of their specific treatment programs and their results. The presentations were followed by panel discussions to stimulate educational debate as to the different forms of treatment for sarcomas and to formulate some conformity in control of disease, control of spread, and ultimate function for the patient. James R. Ryan, M.D."

Biochemical Modulation at the present time defines an area of study in which the intracellular metabolism of a given anti cancer agent is modulated (usually by a noncytotoxic agent or a cytotoxic agent at sufficiently low dosage to make it non cytotoxic) in order to either increase the effectiveness of the particular agent against tumor cells or decrease its cytotox icity against normal cells. The major focus of modulation has been the agents 5-fluorouracil (FUra), arabinofuranosylcytosine (ara-C), methotrexate (MTX) and a few alkylating agents. The major thrust of the studies has been to increase the flow of the anticancer agent along the pathway responsible for the formation of the cytotoxic species: for example, FUra to FUTP or ara-C to ara-CTP. While in most cases the application of research re sults to clinical trials does not require the subsequent exper tise of the laboratory researchers, application of biochemical modulatory schemes to clinical protocols necessitate a dramatic break with the past procedures. As shown in the laboratory clinical loop below, close collaboration between the laboratory and clinical investigator is essential. While the laboratory REDEFINE TECHNOLOGY, TESTS OR QUESTIONS FOR FURTHER THERAPEUTIC ADVANCE CLINICAL EXPERIMENTAL PROTOCOL (LABORATORY) RESEARCH STUDIES DEFINE AND TEST APPROPRIATE SCIENTIFIC PARAMETERS results define rationally-based regimens, it is essential that the clinical protocols contain the requirement that clinical material (either tumor or normal tissues) be sampled to deter mine whether the biochemical modulation being proposed is in fact beinq accomplished.

There have been significant advances in the treatment of sarcomas in the past several years. Further, different clini cal treatment programs are being advocated in different areas including surgery alone, surgery with preoperative or post operative chemotherapy, surgery with different radiotherapy modalities, with each investigator espousing his own treat ment program. On the other side, there is the question of whether these treatment programs are offering better results or whether the natural history of sarcomas has changed. The International Symposium on Sarcomas was held at Innisbrook Resort, Tarpon Springs, Florida, October 8-10, 1987. This was the first international symposium to date involving all of the disciplines treating sarcomas including pathologists, orthopaedic surgeons, general surgeons, medical oncologists, pediatric oncologists, and radiation oncol ogists. The Symposium brought together a number of special ists working in the clinical field of sarcomas for a presen tation of their specific treatment programs and their results. The presentations were followed by panel discussions to stimulate educational debate as to the different forms of treatment for sarcomas and to formulate some conformity in control of disease, control of spread, and ultimate function for the patient. James R. Ryan, M.D."

Biochemical Modulation at the present time defines an area of study in which the intracellular metabolism of a given anti cancer agent is modulated (usually by a noncytotoxic agent or a cytotoxic agent at sufficiently low dosage to make it non cytotoxic) in order to either increase the effectiveness of the particular agent against tumor cells or decrease its cytotox icity against normal cells. The major focus of modulation has been the agents 5-fluorouracil (FUra), arabinofuranosylcytosine (ara-C), methotrexate (MTX) and a few alkylating agents. The major thrust of the studies has been to increase the flow of the anticancer agent along the pathway responsible for the formation of the cytotoxic species: for example, FUra to FUTP or ara-C to ara-CTP. While in most cases the application of research re sults to clinical trials does not require the subsequent exper tise of the laboratory researchers, application of biochemical modulatory schemes to clinical protocols necessitate a dramatic break with the past procedures. As shown in the laboratory clinical loop below, close collaboration between the laboratory and clinical investigator is essential. While the laboratory REDEFINE TECHNOLOGY, TESTS OR QUESTIONS FOR FURTHER THERAPEUTIC ADVANCE CLINICAL EXPERIMENTAL PROTOCOL (LABORATORY) RESEARCH STUDIES DEFINE AND TEST APPROPRIATE SCIENTIFIC PARAMETERS results define rationally-based regimens, it is essential that the clinical protocols contain the requirement that clinical material (either tumor or normal tissues) be sampled to deter mine whether the biochemical modulation being proposed is in fact beinq accomplished."

This year notes two major changes in the annual Detroit Cancer Symposium. The first is our intention of selecting top ics of broad interest to the cancer community and examining the subject from both a basic laboratory and clinical viewpoint. In this way, the importance of both elements of cancer research are noted and the interplay between them emphasized. Further, we believe that Symposia such as this act to stimulate the basic scientist and clinician to continue their studies with the know ledge of the impact that each has upon the other and the nec essary cooperation required to solve the cancer problem. The second change is the publication of this Symposium. The pre vious sixteen were not committed to manuscript form. Given the change in format and intent of the series, we believe that this and subsequent volumes will make important contributions to the cancer literature. The topic of "Biology and Therapy of Acute Leukemia" was chosen for the first Symposium because of its historical signif icance in cancer chemotherapy. The therapeutic rationale for human leukemia is the result of understanding the basic tumor biology largely derived from transplantable leukemias in exper imental animals. It is through these models, as discussed by Dr. Fred Valeriote, that we learned the cellular kinetics of leukemia, the antileukemic effects of new agents and the ef fect of growth perturbation by various chemotherapeutic agents and their combinations."

'A fascinating welcome to the wonderful world of insects' - LoveReading4Kids 'Fun, inspiring, and well researched.' - Kirkus Reviews, starred review A beautifully illustrated tour of some of the world's most fascinating insects, perfect for readers 8+. Did you know that without insects, humankind could not survive? This illustrated, fact-filled title explores the huge variety of insects, with a focus on what makes an insect an insect, the differences between the groups, and why insects are the most important animal group on Earth. Broken down into sections exploring each of the main types of insect, each section takes a different, playfully visual approach to really capture the character of the insects in the order being explored. As well as including practical advice for observing insects safely, a section at the back of the book describes ways to help insects and encourage them into a garden no matter how small.

A beautifully illustrated and atmospheric story exploring how polar bears are coping with climate change; a stunning new addition to the Protecting the Planet series. It snowed last night. The first fall of the season. More is on its way. For this polar bear, this is a sign it's time to make a den, a safe place to sleep through the harsh Arctic winter and to give birth to her cubs. But the Arctic is changing; familiar landscapes are melting. What kind of world will her cubs grow up in? This beautifully illustrated picture book gently explores the effects of climate change on polar bears, along with information on how we can all make a difference and protect the planet for these majestic animals.

'A fascinating welcome to the wonderful world of insects' - LoveReading4Kids 'Fun, inspiring, and well researched.' - Kirkus Reviews, starred review A beautifully illustrated tour of some of the world's most fascinating insects, perfect for readers 8+. Did you know that without insects, humankind could not survive? This illustrated, fact-filled title explores the huge variety of insects, with a focus on what makes an insect an insect, the differences between the groups, and why insects are the most important animal group on Earth. Broken down into sections exploring each of the main types of insect, each section takes a different, playfully visual approach to really capture the character of the insects in the order being explored. As well as including practical advice for observing insects safely, a section at the back of the book describes ways to help insects and encourage them into a garden no matter how small.

"Shoals of tiny, brightly coloured fish dart through the sun-dappled water. Dazzling royal angelfish nibble the coral." Swim through tropical seas and dive into the darkest depths of the ocean to discover Earth's diverse and delicate ecosystems. From vibrant coral reefs to mysterious deep-sea trenches, this lyrical picture book takes you on an amazing journey. Immerse yourself in different ocean landscapes, learn about the diverse range of species, and understand the importance of maintaining these beautiful, natural habitats. This illustrated, lyrical picture book looks at plants, animals and natural formations in Earth's amazing ocean ecosystems, from the smallest creatures to the largest predators, gently covering the topic of global warming. Most of our planet is made up of the ocean, but it is in trouble. With the climate warming, we’re losing the sea ice in the Arctic and Southern Oceans. Every living thing on the planet needs the oceans, including us. This book will inspire you to find out what more you can do to help the oceans, so they can remain wonderful havens of life and beauty that we can all enjoy. Content includes: Coastal Waters Kelp Forests Mangroves Coral Reefs Open Ocean Deep Ocean Frozen Seas The World of Wonder series shines a light on our planet's fragile ecosystems, from majestic mountains, to expansive forests and deep oceans, gently covering important topics such as global warming and the impact of humans on the natural world. Also available: World of Wonder: Mountains  ​978-0-7112-4353-8