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The in vitro antimicrobial and anti-inflammatory activities of
extracts, essential oils and some compounds isolated from six
species of genus Nigella, namely N. arvensis, N. damascena, N.
nigellastrum, N. hispanica, N. orientalis, and N. sativa, are
described in this work. The antimicrobial activities of extracts
from seeds of N. arvensis and N. orientalis, as well as chemical
composition of essential oils from seeds of both species are
reported here. The significant influence of four different
extraction methods on the antimicrobial activity and chemical
composition of N. sativa seed essential is also described. In
addition, the anti-inflammatory effect of four components of N.
arvensis seeds, namely dithymoquinone, thymohydroquinone, thymol
and thymoquinone, has been detected as a result of this research.
This work also summarizes the current knowledge on botany, origin,
geographical distribution, uses, biological effects and chemistry
of all six species. Some suggestions for further research on
chemical and pharmacological properties are also given.
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