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This book focuses on cell culture-produced viral vaccines to meet
the needs of the rapidly expanding research and development in
academia and industry in the field. This book introduces the basic
principles of vaccination and the manufacturing of viral vaccines.
Bioprocessing of Viral Vaccines, will provide an overview of the
advanced strategies needed to respond to the challenges of new and
established viral infection diseases. The first few chapters cover
the basics of virology and immunology as essential concepts to
understand the function and design of viral vaccines. The core of
the content is dedicated to process development, including upstream
processing and cell culture of viral vaccines, downstream
processing, and extensive analytical technologies specific to viral
vaccines. Advanced process analytical technologies (PAT) and
Quality by Design (QbD) concepts are also introduced in the context
of vaccine manufacturing. The case studies included cover
inactivated, attenuated vaccines exemplified by influenza vaccines,
sub-unit vaccines exemplified by Virus Like Particles (VLPs: HPV
vaccines) and sub-unit vaccines (Flublock), vectored vaccines:
adenoviruses and Vesicular stomatitis Virus (VSV) vectored
vaccines, genomic vaccines (DNA and mRNA) vaccines as developed for
COVID-19 response in particular and a review of COVID-19 vaccines
approved or in advanced clinical trials. This book is aimed at
graduate engineers and professionals in the fields of vaccinology,
bioprocessing, and biomanufacturing of viral vaccines.
La nube gris cuenta la historia de una nina muy enfadada que viaja
por el mundo buscando la manera de deshacerse de su enfado. En su
camino encontrara varios personajes que con sus consejos la
ayudaran a eliminarlo. Una bonita historia para ninos de 2 a 4 anos
que ayudara en la gestion de las rabietas propias de la edad. Un
cuento interactivo para los mas pequenos que propone de recursos
para afrontar el enfado.
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