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Shortly after the reeognition of the aequired immunodefieieney
syndrome (AIDS) in 1981 (1-3), it was hypothesized that
herpesviruses may play an important role in the etiology or
pathogenesis of this newly identified syndrome (4,5). This theory
was based on the faet that infeetion with herpesviruses was a
prominent elinieal feature in nearly all patients with AIDS (3-5).
Chronie mueocutaneous herpes simplex virus (HSV) infections were
one of the first opportunistie infeetions deseribed in patients
with AIDS (3), and both cytomegalovirus (CMV) and HSV infections
were extremely common in individuals identified to be at highest
risk for aequiring AIDS, such as homosexual men, intravenous drug
users and hemophiliaes (4-8). CMVand Epstein-Barr virus (EBV) were
also prominent infeetions whieh were suspected as possible
etiologic agents of the prolonged fever, wasting, and
Iymphadenopathy that often precedes AIDS, frequently referred to as
the chronie Iymphadenopathy syndrome (9,10). Subsequent elinieal
studies have indeed demonstrated that infeetions with HSV, CMV,
EBV, and even varieella zoster virus (VZV) are frequent
opportunistic infeetions wh ich oeeur among AIDS patients (11-14).
Several of the opportunistie infeetions caused by herpesviruses
include encephalitis, chorioretinitis, hairy leukoplakia,
esophagitis, enteritis, colitis, Burkitt's lymphoma, primary CNS
lymphoma, zoster, and there has even been speculation about the
role of CMV in the pathogenesis of Kaposi's sareoma (15,16).
Furthermore, the herpesviruses, partieularly CMV and EBV have been
known to be strongly associated with immunosuppression,
partieularly of cell-mediated immune functions, which further
supported the hypothesis that herpesviruses may contribute to the
immune defects that eharacterize AIDS."
Shortly after the reeognition of the aequired immunodefieieney
syndrome (AIDS) in 1981 (1-3), it was hypothesized that
herpesviruses may play an important role in the etiology or
pathogenesis of this newly identified syndrome (4,5). This theory
was based on the faet that infeetion with herpesviruses was a
prominent elinieal feature in nearly all patients with AIDS (3-5).
Chronie mueocutaneous herpes simplex virus (HSV) infections were
one of the first opportunistie infeetions deseribed in patients
with AIDS (3), and both cytomegalovirus (CMV) and HSV infections
were extremely common in individuals identified to be at highest
risk for aequiring AIDS, such as homosexual men, intravenous drug
users and hemophiliaes (4-8). CMVand Epstein-Barr virus (EBV) were
also prominent infeetions whieh were suspected as possible
etiologic agents of the prolonged fever, wasting, and
Iymphadenopathy that often precedes AIDS, frequently referred to as
the chronie Iymphadenopathy syndrome (9,10). Subsequent elinieal
studies have indeed demonstrated that infeetions with HSV, CMV,
EBV, and even varieella zoster virus (VZV) are frequent
opportunistic infeetions wh ich oeeur among AIDS patients (11-14).
Several of the opportunistie infeetions caused by herpesviruses
include encephalitis, chorioretinitis, hairy leukoplakia,
esophagitis, enteritis, colitis, Burkitt's lymphoma, primary CNS
lymphoma, zoster, and there has even been speculation about the
role of CMV in the pathogenesis of Kaposi's sareoma (15,16).
Furthermore, the herpesviruses, partieularly CMV and EBV have been
known to be strongly associated with immunosuppression,
partieularly of cell-mediated immune functions, which further
supported the hypothesis that herpesviruses may contribute to the
immune defects that eharacterize AIDS."
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