Peter Piot, founding executive director of the Joint United Nations Programme on HIV/AIDS (UNAIDS), recounts his experience as a clinician, scientist, and activist fighting the disease from its earliest manifestation to today. The AIDS pandemic was not only disruptive to the health of millions worldwide but also fractured international relations, global access to new technologies, and public health policies in nations across the globe. As he struggled to get ahead of the disease, Piot found science does little good when it operates independently of politics and economics, and politics is worthless if it rejects scientific evidence and respect for human rights.

Piot describes how the epidemic altered global attitudes toward sexuality, the character of the doctor-patient relationship, the influence of civil society in international relations, and traditional partisan divides. AIDS thrust health into national and international politics where, he argues, it rightly belongs. The global reaction to AIDS over the past decade is the positive result of this partnership, showing what can be acheved when science, politics, and policy converge on the ground. Yet it remains a fragile achievement, and Piot warns against complacency and the consequences of reduced investments. He refuses to accept a world in which high levels of HIV infection are the norm. Instead, he explains how to continue to reduce the incidence of the disease to minute levels through both prevention and treatment, until a vaccine is discovered.

Two leading neuroscientists introduce the concepts of cerebral plasticity and the regenerating brain, describing what we know now about the processes through which the brain constantly reconstructs itself and the potential benefits this knowledge might have in addressing concerns for neurological, cognitive, and emotional health. The authors begin with a survey of the fundamental scientific developments that led to our current understanding of the regenerative mind, elucidating some of the breakthrough neurobiological studies that paved the way for our present understanding of the brain's plasticity and regenerative capabilities. They then discuss the application of these findings to such issues as depression, dyslexia, schizophrenia, and cognitive therapy, incorporating the latest technologies in neuroimaging, optogenetics, and nanotechnology. Their work shows the brain is anything but a static organ, ceasing to grow as human beings become adults. Rather, the brain is dynamic, evolving organically in relation to physical, cultural, historical, and affective stimuli, a plasticity that provides great hope to survivors of trauma and degenerative disorders.

Over the past thirty-five years, there has been an explosive increase in scientists' ability to explain the structure and functioning of the human brain. While psychology has advanced our understanding of human behavior, various other sciences, such as anatomy, physiology, and biology, have determined the critical importance of synapses and, through the use of advanced technology, made it possible actually to see brain cells at work within the skull's walls. Here Jean-Pierre Changeux elucidates our current knowledge of the human brain, taking an interdisciplinary approach and explaining in layman's terms the complex theories and scientific breakthroughs that have significantly improved our understanding in the twentieth century.