|
Showing 1 - 3 of
3 matches in All Departments
Based upon a workshop entitled “The Small HSP World” held in
Québec 2-5 October 2014. Twenty-five scientists provided chapters
for the book. The chapters are from the best scientists currently
working in this field. These colleagues include Arrigo,
Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens,
Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen,
Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay,
Vierling, Vigh, Weeks and Wu. Briefly, the book starts with the
structure of small heat shock proteins, moving to their functions
and finishing with their involvement in diseases. Although this is
quite broad, the structural aspect will be the unifying theme of
the book.
L. Nover and L. Hightower Though the roots of experimental stress
biology at the cellular and organismic level can be traced back to
the middle of the last century (Nover 1989), a decisive
breakthrough came only in 1962 with the report on stress-induced
changes of gene activity in Drosophila (Ritossa 1962) and the
subsequent identification of the newly synthesized heat stress
proteins (Tissieres et al. 1974) and mRNAs, respectively (McKenzie
et al1975; McKenzie and Meselson 1977). The selectivity of
induction and the high rate of accumulation of Hsps facilitated the
cloning and sequencing of the hs genes in Drosophila and the
demonstration that all organisms react similarly when exposed to
heat stress or chemical stressors (Ashbumer and Bonner 1979;
Schlesinger et al. 1982; Nover 1984). The explosive development of
molecular stress research in the following 10 years illustrated
that the stress response represents a characteristic network of
dramatic but transient changes at many levels of cellular structure
and function, including gene expression (Atkinson and Walden 1985;
Tomasovic 1989; Georgopoulos et al. 1990; Nover et al. 1990; Nover
1991). Besides the characterization of the hs genes and the
mechanism of their induction, major interest concentrated on the
heat stress proteins and their possible roles in induced stress
tolerance. Rapidly, it became apparent that the major stress
proteins are coded by five conserved multigene families (Lindquist
and Craig 1988: Nover et al.
Based upon a workshop entitled "The Small HSP World" held in Quebec
2-5 October 2014. Twenty-five scientists provided chapters for the
book. The chapters are from the best scientists currently working
in this field. These colleagues include Arrigo, Benesch, Benjamin,
Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie,
Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower,
Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks
and Wu. Briefly, the book starts with the structure of small heat
shock proteins, moving to their functions and finishing with their
involvement in diseases. Although this is quite broad, the
structural aspect will be the unifying theme of the book.
|
|