In the last few years the use of medical imaging has increased exponentially in routine clinical practice. This has been reflected in a rapidly increasing use of medical imaging in clinical trials, through all phases. More recently this has culminated in a number of inter-disciplinary meetings with the various stake holders, including the FDA. Changes in the regulatory process has resulted, when it comes to the submission of data to the FDA, in a therapeutic agent where one or more of the trial end-points is the assessment of a radiological end-point. No longer is it sufficient to have the images read by the local investigator site. The FDA has also identified Medical Imaging as one of the key 6 points in the Critical Path initiative which was launched in 2004. This puts a keen focus on the role of imaging and the need to clearly identify and understand this aspect of clinical trials. As the pharmaceutical, biotech and medical device industry continues to identify ways to improve and speed up product development, medical imaging plays a more significant role. An understanding of the methodology and the metrics is therefore required but difficult to ascertain in one easy to read volume for individuals entering this field. This book will therefore fulfill this void, be it for the pharmaceutical personnel from medical director to monitor, or the Principal Investigator who is having to understand the complexities of the imaging and why it is having to be sent off-site for a 'central read.'

In the 1920s, William Faulkner was an unread and unappreciated author. All his books were out of print. Yet by 1950, he was revered by critics and winner of the Nobel Prize.Schwartz traces how the development of New Criticism, a re-evaluation of his work (the difficulty of his style and depraved subject matter, once considered a negative, were now praised), and the publication of THE PORTABLE FAULKNER all went to make him the most respected writer of the 20th Century.Only about half the book is about Faulkner directly, however; there is also a long chapter on the politics of the new criticism and the intellectual stand of the critics in the 1940s. Some might appreciate this diversion, and much of it is interesting, but for me it went on too long and took away from the main subject of the book. Readers interested in Faulkner's literary career will definitely this book valua