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Translation Mechanisms provides investigators and graduate students
with overviews of recent developments in the field of protein
biosynthesis that are fuelled by the explosive and synergic growth
of structural biology, genomics, and bioinformatics.
The outstanding progress in our understanding of the structure,
dynamics, and evolution of the prokaryotic and eukaryotic
translation machinery, as well as applications in medicine and
biotechnology, are described in 26 chapters covering recent
discoveries on:
-the subtleties of tRNA aminoacylation with natural and
unnatural amino acids.
-the control of mRNA stability, a key step of gene
regulation.
-ribosome structure and function, in the era of the atomic-crystal
resolution of the ribosome.
-the regulation of the biosynthesis of the translational machinery
components.
-the action of a variety of inhibitors of translation and the
prospect for clinical studies.
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