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This book systemically presents the latest research on renal
fibrosis, covering all the major topics in the field, including the
possible mechanisms, biomarkers, and strategies for prevention and
treatment of chronic kidney disease (CKD). Due to its high
prevalence, CKD represents a huge global economic and social
burden. Irrespective of the initial causes, CKD progresses to end
stage kidney disease (ESKD) due to renal fibrosis, which is
characterized by glomerulosclerosis, tubule atrophy and atresia,
and the excessive accumulation of extracellular matrix (ECM) in the
kidney. Unfortunately, an estimated 1%-2% of the adult population
living with CKD will need renal replacement therapy at some point
as a result of ESKD. As such, strategies for preventing or slowing
CKD progression to ESKD are of utmost importance, and studies
aiming to understand the mechanisms of renal fibrosis have been the
focus of intensive research. Recently, novel insights into the
pathophysiological processes have furthered our understanding of
the pathogenesis of renal fibrosis, and more importantly, promoted
studies on the early diagnosis and treatment of CKD. This book
draws lessons from the extensive, state-of-the-art research in this
field, elaborating the new theories and new techniques to offer
readers a detailed and comprehensive understanding of renal
fibrosis and as well as inspiration for future research directions.
This book systemically presents the latest research on renal
fibrosis, covering all the major topics in the field, including the
possible mechanisms, biomarkers, and strategies for prevention and
treatment of chronic kidney disease (CKD). Due to its high
prevalence, CKD represents a huge global economic and social
burden. Irrespective of the initial causes, CKD progresses to end
stage kidney disease (ESKD) due to renal fibrosis, which is
characterized by glomerulosclerosis, tubule atrophy and atresia,
and the excessive accumulation of extracellular matrix (ECM) in the
kidney. Unfortunately, an estimated 1%-2% of the adult population
living with CKD will need renal replacement therapy at some point
as a result of ESKD. As such, strategies for preventing or slowing
CKD progression to ESKD are of utmost importance, and studies
aiming to understand the mechanisms of renal fibrosis have been the
focus of intensive research. Recently, novel insights into the
pathophysiological processes have furthered our understanding of
the pathogenesis of renal fibrosis, and more importantly, promoted
studies on the early diagnosis and treatment of CKD. This book
draws lessons from the extensive, state-of-the-art research in this
field, elaborating the new theories and new techniques to offer
readers a detailed and comprehensive understanding of renal
fibrosis and as well as inspiration for future research directions.
The book compares the differences and similiarity of Singapore and
China, in terms of economy, political system and examines the
possibilites of cooperation in the future.
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