This book constitutes the refereed joint proceedings of the First International Workshop on Machine Learning in Clinical Neuroimaging, MLCN 2018, the First International Workshop on Deep Learning Fails, DLF 2018, and the First International Workshop on Interpretability of Machine Intelligence in Medical Image Computing, iMIMIC 2018, held in conjunction with the 21st International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2018, in Granada, Spain, in September 2018. The 4 full MLCN papers, the 6 full DLF papers, and the 6 full iMIMIC papers included in this volume were carefully reviewed and selected. The MLCN contributions develop state-of-the-art machine learning methods such as spatio-temporal Gaussian process analysis, stochastic variational inference, and deep learning for applications in Alzheimer's disease diagnosis and multi-site neuroimaging data analysis; the DLF papers evaluate the strengths and weaknesses of DL and identify the main challenges in the current state of the art and future directions; the iMIMIC papers cover a large range of topics in the field of interpretability of machine learning in the context of medical image analysis.

This book constitutes the refereed joint proceedings of the 7th Joint International Workshop on Computing and Visualization for Intravascular Imaging and Computer Assisted Stenting, CVII-STENT 2018, and the Third International Workshop on Large-Scale Annotation of Biomedical Data and Expert Label Synthesis, LABELS 2018, held in conjunction with the 21th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2018, in Granada, Spain, in September 2018. The 9 full papers presented at CVII-STENT 2017 and the 12 full papers presented at LABELS 2017 were carefully reviewed and selected. The CVII-STENT papers feature the state of the art in imaging, treatment, and computer-assisted intervention in the field of endovascular interventions. The LABELS papers present a variety of approaches for dealing with few labels, from transfer learning to crowdsourcing.

This book constitutes the refereed joint proceedings of the First International Workshop on OR 2.0 Context-Aware Operating Theaters, OR 2.0 2018, 5th International Workshop on Computer Assisted Robotic Endoscopy, CARE 2018, 7th International Workshop on Clinical Image-Based Procedures, CLIP 2018, and the First International Workshop on Skin Image Analysis, ISIC 2018, held in conjunction with the 21st International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2018, in Granada, Spain, in September 2018. The 11 full papers presented at OR 2.0 2018, the 5 full papers presented at CARE 2018, the 8 full papers presented at CLIP 2018, and the 10 full papers presented at ISIC 2018 were carefully reviewed and selected. The OR 2.0 papers cover a wide range of topics such as machine vision and perception, robotics, surgical simulation and modeling, multi-modal data fusion and visualization, image analysis, advanced imaging, advanced display technologies, human-computer interfaces, sensors. The CARE papers cover topics to advance the field of computer-assisted and robotic endoscopy. The CLIP papers cover topics to fill gaps between basic science and clinical applications. The ISIC papers cover topics to facilitate knowledge dissemination in the field of skin image analysis, as well as to host a melanoma detection challenge, raising awareness and interest for these socially valuable tasks.

This book constitutes the refereed joint proceedings of the International Workshop on Point-of-Care Ultrasound, POCUS 2018, the International Workshop on Bio-Imaging and Visualization for Patient-Customized Simulations, BIVPCS 2017, the International Workshop on Correction of Brainshift with Intra-Operative Ultrasound, CuRIOUS 2018, and the International Workshop on Computational Precision Medicine, CPM 2018, held in conjunction with the 21st International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2018, in Granada, Spain, in September 2018.The 10 full papers presented at POCUS 2018, the 4 full papers presented at BIVPCS 2018, the 8 full papers presented at CuRIOUS 2018, and the 2 full papers presented at CPM 2018 were carefully reviewed and selected. The papers feature research from complementary fields such as ultrasound image systems applications as well as signal and image processing, mechanics, computational vision, mathematics, physics, informatics, computer graphics, bio-medical-practice, psychology and industry. They discuss intra-operative ultrasound-guided brain tumor resection as well as pancreatic cancer survival prediction.

This book constitutes the refereed joint proceedings of the 4th International Workshop on Deep Learning in Medical Image Analysis, DLMIA 2018, and the 8th International Workshop on Multimodal Learning for Clinical Decision Support, ML-CDS 2018, held in conjunction with the 21st International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2018, in Granada, Spain, in September 2018. The 39 full papers presented at DLMIA 2018 and the 4 full papers presented at ML-CDS 2018 were carefully reviewed and selected from 85 submissions to DLMIA and 6 submissions to ML-CDS. The DLMIA papers focus on the design and use of deep learning methods in medical imaging. The ML-CDS papers discuss new techniques of multimodal mining/retrieval and their use in clinical decision support.

This book constitutes the refereed joint proceedings of the Second International Workshop on Graphs in Biomedical Image Analysis, GRAIL 2018 and the First International Workshop on Integrating Medical Imaging and Non-Imaging Modalities, Beyond MIC 2018, held in conjunction with the 21st International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2018, in Granada, Spain, in September 2018. The 6 full papers presented at GRAIL 2018 and the 5 full papers presented at BeYond MIC 2018 were carefully reviewed and selected. The GRAIL papers cover a wide range of develop graph-based models for the analysis of biomedical images and encourage the exploration of graph-based models for difficult clinical problems within a variety of biomedical imaging contexts. The Beyond MIC papers cover topics of novel methods with significant imaging and non-imaging components, addressing practical applications and new datasets

This book constitutes the refereed joint proceedings of the Third International Workshop on Reconstruction and Analysis of Moving Body Organs, RAMBO 2018, the Fourth International Workshop on Breast Image Analysis, BIA 2018, and the First International Workshop on Thoracic Image Analysis, TIA 2018, held in conjunction with the 21st International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2018, in Granada, Spain, in September 2018. The 5 full papers (out of 10 submissions) presented at RAMBO, the 9 full papers (out of 18 submissions) presented at BIA, and the 20 full papers (out of 21 submissions) presented at TIA were carefully reviewed and selected. The RAMBO papers cover aspects of medical imaging where motion plays a role in the image formation or analysis. The BIA papers deal with topics such as computer-aided detection and diagnosis of breast cancer, quantitative analysis of breast imaging modalities, and large scale breast image screening and analysis. The TIA papers cover aspects of image analysis research for lung and cardiac diseases including segmentation, registration, quantification, modeling of the image acquisition process, visualization, validation, statistical modeling, biophysical lung modeling (computational anatomy), deep learning and novel applications.

This book constitutes the refereed joint proceedings of the First International Workshop on Computational Pathology, COMPAY 2018, and the 5th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2018, held in conjunction with the 21st International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2018, in Granada, Spain, in September 2018. The 19 full papers (out of 25 submissions) presented at COMPAY 2018 and the 21 full papers (out of 31 submissions) presented at OMIA 2018 were carefully reviewed and selected. The COMPAY papers focus on artificial intelligence and deep learning. The OMIA papers cover various topics in the field of ophthalmic image analysis.

This book constitutes the refereed joint proceedings of the 6th Joint International Workshop on Computing and Visualization for Intravascular Imaging and Computer Assisted Stenting, CVII-STENT 2017, and the Second International Workshop on Large-Scale Annotation of Biomedical Data and Expert Label Synthesis, LABELS 2017, held in conjunction with the 20th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2017, in Quebec City, QC, Canada, in September 2017. The 6 full papers presented at CVII-STENT 2017 and the 11 full papers presented at LABELS 2017 were carefully reviewed and selected. The CVII-STENT papers feature the state of the art in imaging, treatment, and computer-assisted intervention in the field of endovascular interventions. The LABELS papers present a variety of approaches for dealing with few labels, from transfer learning to crowdsourcing.

The three-volume set LNCS 10433, 10434, and 10435 constitutes the refereed proceedings of the 20th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2017, held inQuebec City, Canada, in September 2017. The 255 revised full papers presented were carefully reviewed and selected from 800 submissions in a two-phase review process. The papers have been organized in the following topical sections: Part I: atlas and surface-based techniques; shape and patch-based techniques; registration techniques, functional imaging, connectivity, and brain parcellation; diffusion magnetic resonance imaging (dMRI) and tensor/fiber processing; and image segmentation and modelling. Part II: optical imaging; airway and vessel analysis; motion and cardiac analysis; tumor processing; planning and simulation for medical interventions; interventional imaging and navigation; and medical image computing. Part III: feature extraction and classification techniques; and machine learning in medical image computing.

The three-volume set LNCS 10433, 10434, and 10435 constitutes the refereed proceedings of the 20th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2017, held inQuebec City, Canada, in September 2017. The 255 revised full papers presented were carefully reviewed and selected from 800 submissions in a two-phase review process. The papers have been organized in the following topical sections: Part I: atlas and surface-based techniques; shape and patch-based techniques; registration techniques, functional imaging, connectivity, and brain parcellation; diffusion magnetic resonance imaging (dMRI) and tensor/fiber processing; and image segmentation and modelling. Part II: optical imaging; airway and vessel analysis; motion and cardiac analysis; tumor processing; planning and simulation for medical interventions; interventional imaging and navigation; and medical image computing. Part III: feature extraction and classification techniques; and machine learning in medical image computing.

The three-volume set LNCS 10433, 10434, and 10435 constitutes the refereed proceedings of the 20th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2017, held inQuebec City, Canada, in September 2017. The 255 revised full papers presented were carefully reviewed and selected from 800 submissions in a two-phase review process. The papers have been organized in the following topical sections: Part I: atlas and surface-based techniques; shape and patch-based techniques; registration techniques, functional imaging, connectivity, and brain parcellation; diffusion magnetic resonance imaging (dMRI) and tensor/fiber processing; and image segmentation and modelling. Part II: optical imaging; airway and vessel analysis; motion and cardiac analysis; tumor processing; planning and simulation for medical interventions; interventional imaging and navigation; and medical image computing. Part III: feature extraction and classification techniques; and machine learning in medical image computing.

Clinical practice is increasingly replacing traditional open surgical procedures with minimally invasive techniques for cancer diagnosis and therapy. These procedures typically require placement of a surgical instrument into the organ of interest with a high degree of accuracy. In general, the success of a treatment or of a diagnosis is highly dependent on the accuracy of instrument insertion and thus depends crucially on the skills and the experience of the physician. While intra-operative navigation has been proven to be highly effective in interventions on bony or sufficiently rigid structures, such as the spine and the brain, computer-assisted soft tissue procedures are still limited to non-invasive diagnostics and surgical planning. This book discusses contemporary approaches in computer-assisted soft tissue interventions. It presents and evaluates a real-time motion compensation method for percutaneous abdominal interventions based on fiducial needles, a guidance method to allow for fast and precise insertion of a needle-shaped instrument along a predetermined trajectory and a respiratory liver motion simulator for evaluating the proposed methods in a realistic setting.