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Scientific interest in regulatory T cells has revived during the
last decade. Initially described in the early seventies as
suppressor T cells, the concept of suppressor/regulatory T cells
went through turbulent times during the eighties when molecular
analysis failed to identify putative suppressor genes. The
constructive and elegant cellular experiments on regulatory T cells
during the nineties, initiated by Shimon Sakaguchi and co-workers,
however have brought these cells back into the limelight. Nowadays,
regulatory T cells are regarded as essential components of the
immune system, and several different subsets of regulatory T cells
have been described. Considerable regulatory function has been
attributed to the CD4+CD25+ T cell subset. These cells act by
suppressing adaptive and possibly also innate immune responses
thereby maintaining or restoring the balance between immunity and
tolerance. The suppressive effects of CD4+CD25+ regulatory T cells
are cell-contact dependent but a role for soluble factors,
particularly in vivo, has been suggested as well.
The aim of this book is to bring together recent developments and
viewpoints in the field of CD4+CD25+ regulatory T cells and to
discuss the potential use of regulatory T cells in immunotherapy of
inflammatory diseases. By linking data on regulatory T cells from
experimental models with recent findings from the clinic, this
topical book will be of interest to immunologists and other
biomedical researchers as well as clinicians that are interested in
regulation and manipulation of the immune response during (chronic)
inflammatory disease.
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