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With its roots in the last century and currently exploiting the
technology of today, the science of drug metabolism has made
significant contributions to our understanding of
chemico-biological interactions. This book reviews past successes
and failures within the science and attempts to predict new
directions. Each of the chapters of this book deals with an aspect
of xenobiotic metabolism which has featured prominently in the
development of the discipline. The volume is testimony to the
breadth and depth of research into xenobiotic metabolism and covers
the chemistry and enzymology of xenobiotic metabolism, enzyme
modeling and structure activity relationships, pharmacokinetics,
the use of recombinant gene technology, site directed mutagenesis,
transgenic and gene knockout models, new analytical techniques
including capillary electrophoresis-mass spectrometry, accelerator
mass spectrometry, high throughput analysis toxicological
assessment, pharmacogenetics, drug development and therapeutics.
With new chemical entities constantly emerging and requiring
evaluation, the concepts and techniques developed in this book will
help focus future lines of investigation and help set priorities in
the next millennium.
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