Antimicrobial Peptides, Volume 663 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on Unifying the classification of antimicrobial peptides in the Antimicrobial Peptide Database, Optimizing peptide library creation for PepSAVI-MS (RP libraries, etc.), Discovery of novel Antimicrobial peptides using BioProspecting, Screening for cysteine-stabilized scaffolds for developing protelytic-resistant AMPs, Exploring synergy and its role in antimicrobial peptide biology, Colorimetric assays for the rapid and high-throughput screening of antimicrobial peptide activity against diverse bacterial pathogens, and much more. Other chapters cover Liquid chromatography-mass spectrometry-based analysis of naturally occurring neuropeptide diastereomers, Multiplexed Quantitative Neuropeptidomics via DiLeu Isobaric Tagging, In vitro evaluation of antibiotic resistance via proteomics, Molecular networking-based strategies in mass spectrometry, Development of Macrocyclic antimicrobial peptides and peptoids, and a host of other timely topics.

This highly topical report provides much-needed evidence to inform the reconfiguration of services for children and young people. Focusing on the Connexions Strategy and service in England, it explores the effectiveness of interagency working in this area. contrasting Connexions Partnerships and around 300 hours of interviews with key stakeholders, young people's Personal Advisers and young people themselves. It examines the interagency strategies developed by the Partnerships and, most importantly, what impact they have had on the interventions made with young people facing acute and complex needs. development; examines interagency work in depth; provides detailed case studies to examine the interface of interagency work with young people's daily lives; analyses key issues in interagency work such as referral, assessment of need, roles, responsibilities and protocols, brokerage of services, advocacy, information sharing and management; draws out the implications of the findings for policy and practice. others involved in partnership working, those involved in the development and implementation of Children and Young People's Strategic Partnerships and Children's Trusts, as well as youth researchers and policy makers.

Managing Children's Homes focuses on leadership, effective management, the allocation of resources, and ensuring positive outcomes for young people in residential care. The book develops an interdisciplinary understanding of what needs to be taken into account when establishing and maintaining good practice on behalf of young people living in children's homes. The authors explain the considerable variation in quality achieved by children's homes and how this relates to management style, working environment and staff structures. The skills and qualities that make effective managers of homes are explored. These, along with factors such as the provision of resources, are investigated to demonstrate how to attain a successful children's home environment and longer-term achievement for looked-after children. Based on innovative, DfES-funded, interdisciplinary research, this book will be essential reading for staff and managers in children's care homes and will also be of interest to students, policy-makers and directors of social services.

Adolescent neglect is a significant problem within child protection, but focus on child neglect and other forms of maltreatment means that it can often be overlooked. This book outlines how adolescent neglect differs from child neglect, the context of why it is overlooked, how it is defined, the causes and consequences of neglect, young people's views, and what professionals can do. Based on original research, the book establishes an evidence base and considers the implications for policy and practice. The concluding chapter sets out a practice-based framework for recognizing and working with adolescent neglect. Each chapter includes reflection points to stimulate thinking on key issues. This will be essential reading for all those who work with young people, particularly those in social work, health services and education, as well as academics, policymakers and students in these fields.