Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

The Targeted Poverty Alleviation programme was proposed by President Xi in 2013 and aims to give poor people the resources to lift themselves out of poverty. No fewer than three million cadres have been sent to the least developed areas of the country to educate, inspire and help the most impoverished people with financial support, jobs and business opportunities. The authors of this series of books visited some of the villages that were previously very poor, to document how developments in education, agriculture, health and tourism had created positive change. The authors wrote about what they saw, what they heard, how they felt in these areas and rendered them into touching and vivid stories. On 3rd November 2013, President Xi visited Shibaidong Village in Western Hunan Province and proposed for the first time 'targeted poverty alleviation', a national solution for reducing poverty. The book describes eighteen representative stories of the villagers in Shibaidong Village in their struggles to get rid of poverty and strive for a well-off life, and each story is told in the first person, flavouring with people's daily life