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Of the thousands of novel compounds that a drug discovery project
team invents and that bind to the therapeutic target, only a
fraction have sufficient ADME (absorption, distribution,
metabolism, elimination) properties, and acceptable toxicology
properties, to become a drug product that will successfully
complete human Phase I clinical trials. Drug-Like Properties:
Concepts, Structure Design and Methods from ADME to Toxicity
Optimization, Second Edition, provides scientists and students the
background and tools to understand, discover, and develop optimal
clinical candidates. This valuable resource explores physiochemical
properties, including solubility and permeability, before exploring
how compounds are absorbed, distributed, and metabolized safely and
stably. Review chapters provide context and underscore the
importance of key concepts such as pharmacokinetics, toxicity, the
blood-brain barrier, diagnosing drug limitations, prodrugs, and
formulation. Building on those foundations, this thoroughly updated
revision covers a wide variety of current methods for the screening
(high throughput), diagnosis (medium throughput) and in-depth (low
throughput) analysis of drug properties for process and product
improvement. From conducting key assays for interpretation and
structural analysis, the reader learns to implement modification
methods and improve each ADME property. Through valuable case
studies, structure-property relationship descriptions, and
structure modification strategies, Drug-Like Properties, Second
Edition, offers tools and methods for ADME/Tox scientists through
all aspects of drug research, discovery, design, development, and
optimization.
The Targeted Poverty Alleviation programme was proposed by
President Xi in 2013 and aims to give poor people the resources to
lift themselves out of poverty. No fewer than three million cadres
have been sent to the least developed areas of the country to
educate, inspire and help the most impoverished people with
financial support, jobs and business opportunities. The authors of
this series of books visited some of the villages that were
previously very poor, to document how developments in education,
agriculture, health and tourism had created positive change. The
authors wrote about what they saw, what they heard, how they felt
in these areas and rendered them into touching and vivid stories.
On 3rd November 2013, President Xi visited Shibaidong Village in
Western Hunan Province and proposed for the first time 'targeted
poverty alleviation', a national solution for reducing poverty. The
book describes eighteen representative stories of the villagers in
Shibaidong Village in their struggles to get rid of poverty and
strive for a well-off life, and each story is told in the first
person, flavouring with people's daily life
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