This book constitutes the refereed proceedings of the 16th China Conference on Wireless Sensor Networks, CWSN 2022, which took place in Guangzhou, China, in November 2022. The 17 full papers presented in this volume were carefully reviewed and selected from 204 submissions, including 87 English papers and 117 Chinese papers. The conference provided an academic exchange of research and a development forum for IoT researchers, developers, enterprises, and users. Exchanging results and experience of research and applications in IoT, and discussing the key challenges and research hotspots, is the main goal of the forum. As a high-level forum for the design, implementation, and application of IoT, the conference promoted the exchange and application of the oriesand technologies of IoT-related topics.