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Leading international experts comprehensively review all aspects of
platinum anticancer drugs and their current use in treatment, as
well as examining their future therapeutic prospects. Writing from
a variety of disciplines, these authorities discuss the chemistry
of cisplatin in aqueous solution, the molecular interaction of
platinum drugs with DNA, and such exciting new areas as DNA
mismatch repair and replicative bypass, apoptosis, and the
transport of platinum drugs into tumor cells. The emergent platinum
drugs of the future-orally active agents, the sterically hindered
ZD0473, and the polynuclear charged platinum BBR3464-are also fully
considered. Timely and interdisciplinary, Platinum-Based Drugs in
Cancer Therapy offers cancer therapeutics specialists an
illuminating survey of every aspect of platinum drugs from
mechanisms of action to toxicology, tumor resistance, and new
analogs.
Leading international experts comprehensively review all aspects of
platinum anticancer drugs and their current use in treatment, as
well as examining their future therapeutic prospects. Writing from
a variety of disciplines, these authorities discuss the chemistry
of cisplatin in aqueous solution, the molecular interaction of
platinum drugs with DNA, and such exciting new areas as DNA
mismatch repair and replicative bypass, apoptosis, and the
transport of platinum drugs into tumor cells. The emergent platinum
drugs of the future-orally active agents, the sterically hindered
ZD0473, and the polynuclear charged platinum BBR3464-are also fully
considered. Timely and interdisciplinary, Platinum-Based Drugs in
Cancer Therapy offers cancer therapeutics specialists an
illuminating survey of every aspect of platinum drugs from
mechanisms of action to toxicology, tumor resistance, and new
analogs.
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