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A compilation of researchers' experience in the areas of
bioanalysis, pharmacokinetics, and drug metabolism, to present an
up-to-date and comprehensive treatise on the application of these
and related technologies in drug discovery, development, and
clinical use. Contents cover descriptions of analytical methods, in
vitro metabolism technology and membrane transport, reappraisal of
classical pharmacokinetic problems, and the time course of drug
action. The book concludes with a description of PET and imaging
methods in pharmacokinetics and an appendix containing a critical
appraisal of computer methods and pharmacokinetic software
available for PCs.
This book contains the papers from invited lecturers as well as
selected contributions presented at the 6th International Meeting
on Clinical Pharmacology in Psychiatry (I.M.C.P.P.) held in Geneva,
Switzerland, 5-7 June 1991. At this meeting the basic theme of the
previous meetings in this series (Chicago 1979, Troms0 1980, Odense
1982, Bethesda 1985, Troms0 1988) was continued, namely, to bridge
the gap between experimental development and clinical reality in
psychopharmacology. After more than 25 years of intensive research
in biological psychiatry, basic understanding of the biological
mechanisms underlying major psychiatric diseases has advanced
significantly but is still far from complete. Likewise, the
hypotheses underlying the development of new psychotropics have
been refined and produced a wide spectrum of novel, yet designed
compounds. The crucial condition for all progress in this field is
reliable, informative clinical testing of new compounds. It is our
hope that this book, as a continuation of the earlier publications
in this series, provides further evidence of the ongoing
interaction between preclinical and clinical scientists, who only
together can assure progress in this exciting area of research and
clinical practice.
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