This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed "nutrition and cancer" from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the "omics") that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions.

The major scientific advancements in the study of nutrition and cancer in the last six years derive from the extensive use of molecular approaches to perform research in the nutritional field. Moreover, the fundamental observation of R. Doll and R. Peto (1981), which suggested that at least 35% of all cancers (with large differences among different tumors) might be prevented by dietary regimens, has been definitively confirmed by epidemiological studies. The molecular studies reported in this volume include all of the major aspects of investigation on human nutrition and malignant transformation. In the last decade a large number of compounds responsible for the biological activity of human foods has been identified and characterized. These molecules not only include important and well-known risk factors but, most promising, compounds, which might exert chemopreventive activity. Among them, antioxidants (such as vitamins, phenols, and lycopene) seem to play a critical role in reducing the risk of cancer at different anatomical sites, including colon, breast, and prostate malignancies. Other molecules, derived from fiber bacterial intestinal degradation (short fatty acids), are of interest, even if their importance has not been completely unraveled and is still the subject of debate.

A pioneering approach to contemporary historical writing on the First Crusade, looking at the texts as cultural artefacts rather than simply for the evidence they contain. The First Crusade (1095-1101) was the stimulus for a substantial boom in Western historical writing in the first decades of the twelfth century, beginning with the so-called "eyewitness" accounts of the crusade and extending to numerous second-hand treatments in prose and verse. From the time when many of these accounts were first assembled in printed form by Jacques Bongars in the early seventeenth century, and even more so since their collective appearance in the great nineteenth-century compendium of crusade texts, the Recueil des historiens des croisades, narrative histories have come to be regarded as the single most important resource for the academic study of the early crusade movement. But our understanding of these texts is still far from satisfactory. This ground-breaking volume draws together the work of an international team of scholars. It tackles the disjuncture between the study of the crusades and the study of medieval history-writing, setting the agenda for future research into historical narratives about or inspired by crusading. The basic premise that informs all the papers is that narrative accounts of crusades and analogous texts should not be primarily understood as repositories of data that contribute to a reconstruction of events, but as cultural artefacts that can be interrogated from a wide range of theoretical, methodological and thematic perspectives. MARCUS BULL is Andrew W. Mellon Distinguished Professor of Medieval and Early Modern Studies at the University of North Carolina at Chapel Hill; DAMIEN KEMPF is Senior Lecturer in Medieval History at the University of Liverpool. Contributors: Laura Ashe, Steven Biddlecombe, Marcus Bull, Peter Frankopan, Damian Kempf, James Naus, Lean Ni Chleirigh, Nicholas Paul, William J. Purkis, Luigi Russo, Jay Rubenstein, Carol Sweetenham,

Analyses of different aspects of the history of warfare in the Mediterranean in the eleventh and twelfth centuries. The kingdom of Sicily plays a huge part in the history of the Norman people; their conquest brought in a new era of invasion, interaction and integration in the Mediterranean, However, much previous scholarship has tended to concentrate on their activities in England and the Holy Land. This volume aims to redress the balance by focusing on the Hautevilles, their successors and their followers. It considers the operational, tactical, technical and logistical aspects of the conduct of war in the South throughout the eleventh and twelfth centuries, looking also at its impact on Italian and Sicilian multi-cultural society. Topics include the narratives of the Norman expansion, exchanges and diffusion between the "military cultures" of the Normans and the peoples they encountered in the South, and their varied policies of conquest, consolidation and expansion in the different operational theatres of land and sea.

This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed “nutrition and cancer” from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the “omics”) that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions.

This volume includes contributions presented at the Second International Sym posium on Nutrition and Cancer, held in Naples, Italy, in October 1998 at the National Tumor Institute "Fondazione Pascale." During the Conference, experts from different disciplines discussed pivotal and timely subjects on the interactions between human nutrition and the development of malignancies. Comparing the themes of this Meeting with those discussed at the First Sympo sium in 1992, the major scientific advancements certainly derive from the extensive use of molecular approaches to perform research in nutrition. Moreover, the fundamental observation of R. Doll and R. Peto (1981), which suggested that at least 35% of all cancers (with large differences among different tumors) might be prevented by dietary regimens, has been definitively confirmed by epidemiological studies. On the other hand, the relationships between diet and cancer are quite intricate and complex; it is difficult, and at the same time not methodologically correct, to reduce them to simple terms. Metabolic and hormonal factors, contaminants and biological agents, and deficiency of specific protective nutrients are all pieces of the same puzzle."

A pioneering approach to contemporary historical writing on the First Crusade, looking at the texts as cultural artefacts rather than simply for the evidence they contain. The First Crusade (1095-1101) was the stimulus for a substantial boom in Western historical writing in the first decades of the twelfth century, beginning with the so-called "eyewitness" accounts of the crusade and extending to numerous second-hand treatments in prose and verse. From the time when many of these accounts were first assembled in printed form by Jacques Bongars in the early seventeenth century, and even more so since their collective appearance in the great nineteenth-century compendium of crusade texts, the Recueil des historiens des croisades, narrative histories have come to be regarded as the single most important resource for the academic study of the early crusade movement. But our understanding of these texts is still far from satisfactory. This ground-breaking volume draws together the work of an international team of scholars. It tackles the disjuncture between the study of the crusades and the study of medieval history-writing, setting the agenda for future research into historical narratives about or inspired by crusading. The basic premise that informs all the papers is that narrative accounts of crusades and analogous texts should not be primarily understood as repositories of data that contribute to a reconstruction of events, but as cultural artefacts that can be interrogated from a wide range of theoretical, methodological and thematic perspectives. MARCUS BULL is Andrew W Mellon Distinguished Professor of Medieval and Early Modern Studies at the University of North Carolina at Chapel Hill; DAMIEN KEMPF is Senior Lecturer in Medieval History at the University of Liverpool. Contributors: Laura Ashe, Steven Biddlecombe, Marcus Bull, Peter Frankopan, Damian Kempf, James Naus, Lean Ni Chleirigh, Nicholas Paul, William J. Purkis, Luigi Russo, Jay Rubenstein, Carol Sweetenham,

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.