This book constitutes the refereed proceedings of the 5th Ibero-American Congress on Smart Cities, ICSC-Cities 2022, held in Cuenca, Ecuador during November 28–30, 2022.  The 17 full papers included in this book were carefully reviewed and selected from 116 submissions. They were organized in topical sections as follows: computational intelligence and urban informatics for smart cities, Internet of things, optimization, smart production, and smart public services and smart monitoring and communications