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Showing 1 - 15 of 15 matches in All Departments

The Adventures of Larry the Hot Dog - Fred the Farmer (Hardcover): M C Dixon The Adventures of Larry the Hot Dog - Fred the Farmer (Hardcover)
M C Dixon; Illustrated by 1000 Storybooks
R601 Discovery Miles 6 010 Ships in 10 - 15 working days
The Adventures of Larry the Hot Dog - Sam the Lineman (Hardcover): M C Dixon The Adventures of Larry the Hot Dog - Sam the Lineman (Hardcover)
M C Dixon; Illustrated by 1000 Storybooks
R569 Discovery Miles 5 690 Ships in 12 - 17 working days
The Adventures of Larry the Hot Dog - Pete the Policeman (Hardcover): M C Dixon The Adventures of Larry the Hot Dog - Pete the Policeman (Hardcover)
M C Dixon; Illustrated by 1000 Storybooks
R533 Discovery Miles 5 330 Ships in 12 - 17 working days
The Adventures of Larry the Hot Dog - Karl the Construction Worker (Hardcover): M C Dixon The Adventures of Larry the Hot Dog - Karl the Construction Worker (Hardcover)
M C Dixon; Illustrated by 1000 Storybooks
R460 Discovery Miles 4 600 Ships in 12 - 17 working days
Cardiac Remodeling and Failure (Hardcover, 2003 ed.): Pawan K. Singal, Ian M.C. Dixon, Lorrie A. Kirshenbaum, Naranjan S. Dhalla Cardiac Remodeling and Failure (Hardcover, 2003 ed.)
Pawan K. Singal, Ian M.C. Dixon, Lorrie A. Kirshenbaum, Naranjan S. Dhalla
R8,354 Discovery Miles 83 540 Ships in 12 - 17 working days

According to the World Health Report (2000 http:/ /www. who. int/whr), of the 55 million deaths worldwide in 1999, more than 16 million were secondary to car diovascular complications. With the prospect of world population increasing from the current level of 6 billion to 9 billion by the middle of this century, the burden of cardiac disease is going to increase astronomically. Furthermore, scientists are being challenged not only to reduce mortality, but also to improve quality of life. Thus, more than ever, intellectuals from different disciplines including biology, sociology, informatics and health care have to join forces to meet the mandate. The World Heart Congress with a focus on "Frontiers in Cardiovascular Health" held in Winnipeg during July 6-11, 2001, made a unique attempt to bring these specialists together to brainstorm and map out the course of action for cardiovascular research and health in the next century. Anytime there is a relative increase in the workload on the heart, there are adap tive myocardial as well as humoral responses. When these adaptations or remodel ing at the organ, subcellular or gene level, become inadequate for a proper tissue perfusion, the condition of heart failure ensues. Prevention of the factors leading to the relative increase in workload as well as a better understanding of the adap tive responses and their failure are some of the hopes to combat the morbidity and mortality due to heart failure.

Mechanisms of Heart Failure (Hardcover, 1995 ed.): Pawan K. Singal, Ian M.C. Dixon, Robert E. Beamish, Naranjan S. Dhalla Mechanisms of Heart Failure (Hardcover, 1995 ed.)
Pawan K. Singal, Ian M.C. Dixon, Robert E. Beamish, Naranjan S. Dhalla
R5,856 Discovery Miles 58 560 Ships in 10 - 15 working days

Mechanisms of Heart Failure is based on papers selected from poster presentations made at the International Conference on Heart Failure, Winnipeg, May 20-23, 1994. Although the entire book is one continuous discussion of subcellular mechanisms of heart failure and its treatment, the presentation has been divided into three sections: the opening section on the subcellular basis of heart failure includes discussions of cytokines, signal transduction, metabolism, extracellular matrix, organ level changes and newer approaches to understanding the pathogenesis of heart failure. The second section focuses on the pathophysiological aspects of cardiomyopathies and their treatment. In the final section, medical, surgical and pharmacological approaches to the treatment of heart failure are discussed in clinical and animal laboratory settings.

Cardiac Fibrosis and Heart Failure: Cause or Effect? (Hardcover, 2015 ed.): Ian M.C. Dixon, Jeffrey T. Wigle Cardiac Fibrosis and Heart Failure: Cause or Effect? (Hardcover, 2015 ed.)
Ian M.C. Dixon, Jeffrey T. Wigle
R4,936 Discovery Miles 49 360 Ships in 12 - 17 working days

The unique biology of cardiac fibroblasts and related cells, such as cardiac myofibroblasts and valvular interstitial cells, distinguish them from other fibroblastic cells, a concept that is only beginning to be widely appreciated. Further, the natural signals that stimulate and inhibit cardiac fibrosis within these cells are not well understood. This volume compiles articles that address the molecular mechanisms that control the synthesis and secretion of the cardiac ECM. The book showcases chapters that highlight discussion of role of Transforming Growth Factor (TGF ), an important fibrogenic cytokine and its downstream effectors SMAD in many cardiac diseases. Further, the contributions highlight information to discuss endogenous inhibitors of cardiac fibrosis, as well as advances in tissue engineering specific to matrix in the heart. Finally, discussions of unifying mechanisms of matrix remodeling in valves and myocardium are presented. The mechanisms involved in the stimulation of cardiac fibrosis are not fully understood. In most cases the marginal attenuation of cardiac fibrosis as a result of a given therapy is a beneficial side-effect linked to other primary effects on other cells, especially cardiomyocytes. Very few drugs or agents are known to affect the function and dysfunction of cardiac fibroblasts and myofibroblasts alone. The book helps to translate the information gathered within to allow us to alter the course of fibrogenic events that are typical of cardiac fibrosis, and thereby reduce their burden on the patient and on society itself.

Angiotensin II Receptor Blockade Physiological and Clinical Implications (Hardcover, 1998 ed.): Naranjan S. Dhalla, Peter... Angiotensin II Receptor Blockade Physiological and Clinical Implications (Hardcover, 1998 ed.)
Naranjan S. Dhalla, Peter Zahradka, Ian M.C. Dixon, Robert E. Beamish
R8,448 Discovery Miles 84 480 Ships in 12 - 17 working days

The relationship between angiotensin II and hypertension was established in 1898 when angiotensin II was shown to modulate systemic blood pressure. Over the intervening decades, a complete characterization of the renin-angiotensin system (RAS) has been achieved, and our understanding of its biochemistry and physiology has led to the directed development of agents such as ACE inhibitors and receptor antagonists capable of controlling hypertension. More recently, it was shown that angiotensin II is secreted within certain tissues, and that these tissue-specific systems operate independently of the systemic RAS. The novel concept that angiotensin II regulates a number of cardiovascular processes that are unrelated to blood pressure has renewed the interest of both basic and clinical scientists in angiotensin II. The association between angiotensin II and cardiac growth, in particular, has indicated that therapies currently in use for hypertension may have direct application to the treatment of heart failure. Angiotensin II Receptor Blockade: Physiological and Clinical Implications focuses on the most recent developments in the molecular biology, cellular physiology and structure-function relationships of angiotensin II and its receptors. In addition, this volume covers the current therapeutic uses for angiotensin receptor antagonists and considers their potential future applications. This volume will be a valuable resource for scientists, practising clinicians and students who are attempting to extend their knowledge in the field of hypertension and heart failure, and who are devoted to improving cardiovascular health.

The Adventures of Larry the Hot Dog - Gary the Garbage Man (Hardcover): M C Dixon The Adventures of Larry the Hot Dog - Gary the Garbage Man (Hardcover)
M C Dixon; Illustrated by 1000 Storybooks
R585 Discovery Miles 5 850 Ships in 9 - 15 working days
Cardiac Fibrosis and Heart Failure: Cause or Effect? (Paperback, Softcover reprint of the original 1st ed. 2015): Ian M.C.... Cardiac Fibrosis and Heart Failure: Cause or Effect? (Paperback, Softcover reprint of the original 1st ed. 2015)
Ian M.C. Dixon, Jeffrey T. Wigle
R5,616 Discovery Miles 56 160 Ships in 10 - 15 working days

The unique biology of cardiac fibroblasts and related cells, such as cardiac myofibroblasts and valvular interstitial cells, distinguish them from other fibroblastic cells, a concept that is only beginning to be widely appreciated. Further, the natural signals that stimulate and inhibit cardiac fibrosis within these cells are not well understood. This volume compiles articles that address the molecular mechanisms that control the synthesis and secretion of the cardiac ECM. The book showcases chapters that highlight discussion of role of Transforming Growth Factor (TGF ), an important fibrogenic cytokine and its downstream effectors SMAD in many cardiac diseases. Further, the contributions highlight information to discuss endogenous inhibitors of cardiac fibrosis, as well as advances in tissue engineering specific to matrix in the heart. Finally, discussions of unifying mechanisms of matrix remodeling in valves and myocardium are presented. The mechanisms involved in the stimulation of cardiac fibrosis are not fully understood. In most cases the marginal attenuation of cardiac fibrosis as a result of a given therapy is a beneficial side-effect linked to other primary effects on other cells, especially cardiomyocytes. Very few drugs or agents are known to affect the function and dysfunction of cardiac fibroblasts and myofibroblasts alone. The book helps to translate the information gathered within to allow us to alter the course of fibrogenic events that are typical of cardiac fibrosis, and thereby reduce their burden on the patient and on society itself.

Biochemistry of Hypertrophy and Heart Failure (Paperback, Softcover reprint of the original 1st ed. 2003): Lorrie A.... Biochemistry of Hypertrophy and Heart Failure (Paperback, Softcover reprint of the original 1st ed. 2003)
Lorrie A. Kirshenbaum, Ian M.C. Dixon, Pawan K. Singal
R2,860 Discovery Miles 28 600 Ships in 10 - 15 working days

The focus of this special issue of Molecular and Cellular Biochemistry is underlying mechanisms that regulate cardiac growth. The new information provided in this special issue can be utilized to design new treatment modalities that will reduce the incidence of cardiac failure which will improve quality of life in patients with chronic heart disease.

Mechanisms of Heart Failure (Paperback, Softcover reprint of the original 1st ed. 1995): Pawan K. Singal, Ian M.C. Dixon,... Mechanisms of Heart Failure (Paperback, Softcover reprint of the original 1st ed. 1995)
Pawan K. Singal, Ian M.C. Dixon, Robert E. Beamish, Naranjan S. Dhalla
R5,625 Discovery Miles 56 250 Ships in 10 - 15 working days

Mechanisms of Heart Failure is based on papers selected from poster presentations made at the International Conference on Heart Failure, Winnipeg, May 20-23, 1994. Although the entire book is one continuous discussion of subcellular mechanisms of heart failure and its treatment, the presentation has been divided into three sections: the opening section on the subcellular basis of heart failure includes discussions of cytokines, signal transduction, metabolism, extracellular matrix, organ level changes and newer approaches to understanding the pathogenesis of heart failure. The second section focuses on the pathophysiological aspects of cardiomyopathies and their treatment. In the final section, medical, surgical and pharmacological approaches to the treatment of heart failure are discussed in clinical and animal laboratory settings.

New Perspectives on the Sierra Leone Krio (Hardcover): Mac Dixon-Fyle, Gibril Raschid Cole New Perspectives on the Sierra Leone Krio (Hardcover)
Mac Dixon-Fyle, Gibril Raschid Cole
R2,285 Discovery Miles 22 850 Ships in 12 - 17 working days

The ex-slave, Krio population of Freetown, Sierra Leone - an amalgam of ethnicities drawn from several parts of the African continent - is a fascinating study in hybridity, creolization, European cultural penetration, the retention of African cultural values, and the interface between New World returnees and autochthonous populations of West Africa. Although its Nigerian connections are often acknowledged, insufficient attention has been paid to the indigenous Sierra Leonean roots of this community. This anthology addresses this problem, while celebrating the complexities of Krio identity in Krio interaction with other ethnic groups and nationalities in the British colonial experience.

Angiotensin II Receptor Blockade Physiological and Clinical Implications (Paperback, Softcover reprint of the original 1st ed.... Angiotensin II Receptor Blockade Physiological and Clinical Implications (Paperback, Softcover reprint of the original 1st ed. 1998)
Naranjan S. Dhalla, Peter Zahradka, Ian M.C. Dixon, Robert E. Beamish
R8,380 Discovery Miles 83 800 Ships in 10 - 15 working days

The relationship between angiotensin II and hypertension was established in 1898 when angiotensin II was shown to modulate systemic blood pressure. Over the intervening decades, a complete characterization of the renin-angiotensin system (RAS) has been achieved, and our understanding of its biochemistry and physiology has led to the directed development of agents such as ACE inhibitors and receptor antagonists capable of controlling hypertension. More recently, it was shown that angiotensin II is secreted within certain tissues, and that these tissue-specific systems operate independently of the systemic RAS. The novel concept that angiotensin II regulates a number of cardiovascular processes that are unrelated to blood pressure has renewed the interest of both basic and clinical scientists in angiotensin II. The association between angiotensin II and cardiac growth, in particular, has indicated that therapies currently in use for hypertension may have direct application to the treatment of heart failure.Angiotensin II Receptor Blockade: Physiological and Clinical Implications focuses on the most recent developments in the molecular biology, cellular physiology and structure-function relationships of angiotensin II and its receptors. In addition, this volume covers the current therapeutic uses for angiotensin receptor antagonists and considers their potential future applications. This volume will be a valuable resource for scientists, practising clinicians and students who are attempting to extend their knowledge in the field of hypertension and heart failure, and who are devoted to improving cardiovascular health.

Cardiac Remodeling and Failure (Paperback, Softcover reprint of the original 1st ed. 2003): Pawan K. Singal, Ian M.C. Dixon,... Cardiac Remodeling and Failure (Paperback, Softcover reprint of the original 1st ed. 2003)
Pawan K. Singal, Ian M.C. Dixon, Lorrie A. Kirshenbaum, Naranjan S. Dhalla
R8,358 Discovery Miles 83 580 Ships in 10 - 15 working days

According to the World Health Report (2000 http:/ /www. who. int/whr), of the 55 million deaths worldwide in 1999, more than 16 million were secondary to car diovascular complications. With the prospect of world population increasing from the current level of 6 billion to 9 billion by the middle of this century, the burden of cardiac disease is going to increase astronomically. Furthermore, scientists are being challenged not only to reduce mortality, but also to improve quality of life. Thus, more than ever, intellectuals from different disciplines including biology, sociology, informatics and health care have to join forces to meet the mandate. The World Heart Congress with a focus on "Frontiers in Cardiovascular Health" held in Winnipeg during July 6-11, 2001, made a unique attempt to bring these specialists together to brainstorm and map out the course of action for cardiovascular research and health in the next century. Anytime there is a relative increase in the workload on the heart, there are adap tive myocardial as well as humoral responses. When these adaptations or remodel ing at the organ, subcellular or gene level, become inadequate for a proper tissue perfusion, the condition of heart failure ensues. Prevention of the factors leading to the relative increase in workload as well as a better understanding of the adap tive responses and their failure are some of the hopes to combat the morbidity and mortality due to heart failure.

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