Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine.

Along with its companion volume on intraflagellar transport, this book provides researchers with a comprehensive and up-to-date source of methods for the analysis cilia and flagella, focusing primarily on approaches that have been devised or significantly extended since the last volume of Methods in Cell Biology on this topic (volume 47, 1995). Edited by Stephen M. King and Gregory J. Pazour, the newest installment of this highly acclaimed serial will serve as an essential addition to the study of cilia and flagella.

* Covers protocols for cilia and flagella across systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Cilia are highly conserved organelles that serve motile functions, sensory functions, or both. These organelles power cell movement, generate fluid flow in various organs, act as sensors of the extracellular environment and have been modified for various specialized tasks such as light reception and smell. Defects in these ubiquitous organelles lead to a broad array of human genetic disorders that range from polycystic kidney disease, retinal degeneration, epilepsy and infertility to developmental defects such as situs inversus and polydactyly. This volume is the third in a three-part series on cilia that focuses on the use of model organisms to gain insight into ciliary function and on the process of intraflagellar transport that is essential for the assembly and maintenance of ciliary structures.

* Includes both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Covers forward and reverse genetic analysis of IFT and biochemical methods to define the role of IFT components * Methods presented cover molecular, genetic, and biochemical approaches to ciliary function in model organisms"

Along with its companion volume on axonemal dynein-mediated motility, this book provides researchers with a comprehensive and up-to-date source of methods for the analysis cilia and flagella, focusing primarily on approaches that have been devised or significantly extended since the last volume of Methods in Cell Biology on this topic (volume 47, 1995). Edited by Stephen M. King and Gregory J. Pazour, the newest installment of this highly acclaimed serial will serve as an essential addition to the study of cilia and flagella.

* Covers protocols for cilia and flagella across systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Jung's Four and Some Philosophers provides a context in which to understand the widely differing claims of philosophers. The "four" in the title refers to the four faculties that Jung sees in every psyche. These faculties occur in pairs: thinking and feeling, sensation and intuition. One of these faculties will dominate and determine one's psychological type -- among philosophers it characterizes what they find self-evident. If thinking dominates, its opposite (feeling) is repressed to the unconscious, and vice versa. If intuition dominates, sensation is repressed, and vice versa. To achieve wholeness, the individual must seek the repressed faculty in the mysterious unconscious and then integrate it with the other three conscious faculties.

Jung's Four and Some Philosophers is a valuable source for all students and teachers of philosophy, Jungian analysts, counselors, and spiritual directors, and those seeking a common wisdom in the great philosophers.

Draws from a diverse range of literature, including history, philosophy, public administration, leadership, religion, and spirituality, to explore what it means to be an ethical and moral leader. Takes a deep dive into the many challenges of leadership, examining the continuing contrast between bureaucracy and democracy, the unique ethical and moral characteristics of nonprofit and faith-based organizations, and the globalization of organizations and institutions. Develops a more holistic and interdisciplinary understanding of ethical and moral leadership, required for more thoughtful theoretical and empirical research.

Experts from academia, clinical settings, and the business world pool their knowledge about work injury prevention and management in the new Sourcebook of Occupational Rehabilitation. The 22 contributions in this wide-ranging reference address aspects of the three primary areas of service delivery: prevention, assessment, and rehabilitation. The text takes a multidisciplinary viewpoint toward its subject in order to shed light on the mechanisms and management of work-related disorders. It boasts a wealth of current and in-depth information, and takes a practical `applications approach' to rehabilitation

Newest research into drama and performance of the Middle Ages and Tudor period. Medieval English Theatre is the premier journal in early theatre studies. Its name belies its wide range of interest: it publishes articles on theatre and pageantry from across the British Isles up to the opening of the London playhouses and the suppression of the civic religious plays , and also includes contributions on European and Latin drama, together with analyses of modern survivals or equivalents, and of research productions of medieval plays. The papers in this volume explore richly interlocking topics. Themes of royalty and play continue from Volume 43. We have the first in-depth examination of the employment of the now-famous Black Tudor trumpeter, John Blanke, at the royal courts of Henry VII and Henry VIII. An entertaining survey of the popular European game of blanket-tossing accompanies the translation of a raucous, sophisticated, but surprisingly humane Dutch rederijkers farce. The Towneley plays remain fertile ground for further research, and this blanket-tossing farce illuminates a key scene of the well-known Second Shepherd's Play. New exploration of a colloquial reference to 'Stafford Blue' in another Towneley pageant, Noah, not only enlivens the play's social context but contributes to important current re-thinking of the manuscript's date. Two papers bring home the theatrical potential of food and eating. We learn how the Tudor interlude Jacob and Esau dramatises the preparation and provision of food from the Genesis story. Serving and eating meals becomes a means of social, theological, and theatrical manipulation. Contrastingly, in the N. Town Last Supper play and a French convent drama, we see how the bread of Passover, the Last Supper, and the Mass could be evoked, layered and shared in performance. In both these plays the audiences' experiences of theatre and of communion overlap and inform each other.

Routledge is now re-issuing this prestigious series of 204 volumes originally published between 1910 and 1965. The titles include works by key figures such asC.G. Jung, Sigmund Freud, Jean Piaget, Otto Rank, James Hillman, Erich Fromm, Karen Horney and Susan Isaacs. Each volume is available on its own, as part of a themed mini-set, or as part of a specially-priced 204-volume set. A brochure listing each title in the "International Library of Psychology" series is available upon request.

Draws from a diverse range of literature, including history, philosophy, public administration, leadership, religion, and spirituality, to explore what it means to be an ethical and moral leader. Takes a deep dive into the many challenges of leadership, examining the continuing contrast between bureaucracy and democracy, the unique ethical and moral characteristics of nonprofit and faith-based organizations, and the globalization of organizations and institutions. Develops a more holistic and interdisciplinary understanding of ethical and moral leadership, required for more thoughtful theoretical and empirical research.

An investigation into the connections between the York Plays, religious observance, and the role played by the city itself. WINNER of the 2007 David Bevington Prize The York Play is the earliest near-complete English civic mystery cycle. It evolved constantly throughout its long performance history, but the text that was recorded in the YorkRegister shows that it was already a mature and elaborate civic festival by the time it was written down. This study uncovers the Cycle's connection with worship in York, in the sense both of devotional practice and of civichonour, informing a particular period in the cultural history of the city. The pageants in the Register show in their different ways how the community which devised and performed the Cycle regarded the celebration of the great summer feast of Corpus Christi. Moreover the principles of selection that give the Cycle its structure reflect the broader pattern of the liturgical calendar, with its other feasts and fasts. The Cycle bears witness not only to thepractices of religious observance in York, but also to the ecclesiastical politics in which the city was caught up from the very beginning of the fifteenth century. PAMELA KING is Professor of Medieval Studies at the University of Bristol.

Niklas Luhmann's social theory stands in direct opposition to the dominant "anthropocentric" traditions of legal and political analysis. King and Thornhill now offer the first comprehensive, critical examination of Luhmann's highly original theory of the operations of the legal and political systems. They describe how from the perspective of his "sociological enlightenment" Luhmann continually calls to account the certainties, the ambitions and rational foundations of The Enlightenment and the idealized versions of law and politics that they have produced.

The role of cognitive and socioemotional skills alongside education in determining people's success in the labour market has been the topic of a growing body of research - but previous studies have mostly missed middle-income countries and the developing world because measures of those skills and data on employment and earnings on large enough samples of adults have typically not been available. Using comparable survey data on these schooling, skills and labour market outcomes from 13 developing and emerging economies worldwide, this book revisits human capital and gender inequality models. It presents new estimates of the returns to different levels of schooling as well as cognitive and socioemotional skills for women and men. It examines whether those returns are due to levels of human capital or to structural bias in labour markets, and how these two factors work across the earnings spectrum. The book examines the existence of 'glass ceilings' and 'sticky floors' for women using this expanded measure of human capital. Further, by analyzing a group of countries of wide-ranging levels of economic development and socio-political contexts, the book reveals patterns and insights into how context mediates the relationship between skills and gender gaps in labour market outcomes. This book will be of interest to scholars of human capital and gender inequality in the labour market and development economics, as well as gender and development policy makers.

This volume brings together nineteen important articles by Pamela M. King, one of the foremost British scholars working on Early English Drama. Unique to this collection are five articles on the 'living' traditions of performances in Spain, discussing their origins and the modes of production that are used. Several articles use modern literary theory on aspects of early drama, whilst others consider drama in the context of late medieval poetry. The volume also includes a rich collection of articles on English scriptural plays from surviving manuscripts.

The story of invasive species in New Zealand is unlike any other in the world. By the mid-thirteenth century, the main islands of the country were the last large landmasses on Earth to remain uninhabited by humans, or any other land mammals. New Zealand's endemic fauna evolved in isolation until first Polynesians, and then Europeans, arrived with a host of companion animals such as rats and cats in tow. Well-equipped with teeth and claws, these small furry mammals, along with the later arrival of stoats and ferrets, have devastated the fragile populations of unique birds, lizards and insects. Carolyn M. King brings together the necessary historical analysis and recent ecological research to understand this long, slow tragedy. As a comprehensive historical perspective on the fate of an iconic endemic fauna, this book offers much-needed insight into one of New Zealand's longest-running national crises.

While many introductory public administration textbooks contain a dedicated chapter on ethics, The Public Administration Profession is the first to utilize ethics as a lens for understanding the discipline. Analyses of the ASPA Code of Ethics are deftly woven into each chapter alongside complete coverage of the institutions, processes, concepts, persons, history, and typologies a student needs to gain a thorough grasp of public service as a field of study and practice. Features include: A significant focus on "public interests," nonprofit management, hybrid-private organizations, contracting out and collaborations, and public service at state and local levels. A careful examination of the role that religion may play in public servants' decision making, as well as the unignorable and growing role that faith-based organizations play in public administration and nonprofit management at large. End-of-chapter ethics case studies, key concepts and persons, and dedicated "local community action steps" in each chapter. Appendices dedicated to future public administration and nonprofit career management, writing successful papers throughout a student's career, and professional codes of ethics. A comprehensive suite of online supplements, including: lecture slides; quizzes and sample examinations for undergraduate and graduate courses containing multiple choice, true-false, identifications, and essay questions; chapter outlines with suggestions for classroom discussion; and suggestions for use of appendices, e.g., how to successfully write a short term paper, a brief policy memo, resume, or a book review. Providing students with a comprehensive introduction to the subject while offering instructors an elegant new way to bring ethics prominently into the curriculum, The Public Administration Profession is an ideal introductory text for public administration and public affairs courses at the undergraduate or graduate level.

Dyneins: Structure, Biology and Disease, Second Edition, offers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer. Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease.

Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters. Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology.

What, according to the Book of Amos, does it mean to be the people of God? In this book, Andrew M. King employs a Social Identity Approach (SIA), comprised of Social Identity Theory and Self-Categorization Theory, to explore the relationship between identity formation and the biblical text. Specifically, he examines the identity-forming strategies embedded in the Book of Amos. King begins by outlining the Social Identity Approach, especially its use in Hebrew Bible scholarship. Turning to the Book of Amos, he analyzes group dynamics and intergroup conflicts (national and interpersonal), as well as Amos’s presentation of Israel’s history and Israel’s future. King provides extensive insight into the rhetorical strategies in Amos that shape the trans-temporal audience’s sense of self. To live as the people of God, according to Amos, readers and hearers must adopt norms defined by a proper relationship to God that results in the proper treatment of others.

First Published in 1999. This text is the author's attempt to orgnaise the field of psychology for students. This volume make a critical examination of various psychological and semi-pstchological attempts to classify fundamental human activities; and thereafter attempts to postulate elementary behaviour units which may serve psychology precisely as the atom and electron have served in chemistry.

"Bacterial Biogeochemistry, Third Edition" focuses on bacterial metabolism and its relevance to the environment, including the decomposition of soil, food chains, nitrogen fixation, assimilation and reduction of carbon nitrogen and sulfur, and microbial symbiosis. The scope of the new edition has broadened to provide a historical perspective, and covers in greater depth topics such as bioenergetic processes, characteristics of microbial communities, spatial heterogeneity, transport mechanisms, microbial biofilms, extreme environments and evolution of biogeochemical cycles.
Provides up-to-date coverage with an enlarged scope, a new historical perspective, and coverage in greater depth of topics of special interestCovers interactions between microbial processes, atmospheric composition and the earth's greenhouse propertiesCompletely rewritten to incorporate all the advances and discoveries of the last 20 years such as applications in the exploration for ore deposits and oil and in remediation of environmental pollution