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The blood basophils lead a shadowy existence in the field of
hematology, even now, 100 years after their discovery by PAUL
EHRLICH. In clinical medicine they were hardly noticed for many
decades, since they occur in such small numbers in the blood that
small and moderate variations in the basophil count were not
detectable with common count ing methods. This situation has
changed since the in troduction of direct counting methods. It was
noticed, for example, that the blood basophil count is increased in
hy perlipemia. In the field of pathology the blood basophil was
prac tically overlooked until recently. This was due to the fact
that with common fixations in aqueous solutions the granules
dissolve, so that the cells can no longer be stained specifically
and therefore escape observation. This problem was solved through
special fixing solu tions. However, interest in the blood basophils
remain ed confined to only a few research groups.
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