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In this book the first three chapters outline the chemistry of
nickel and heme largely associated with anaerobic life and believed
to represent reactions which took place some 3-4x109years ago.
Nickel has disappeared from the chemistry of man. The fascinating
detail of the "primitive" catalysts is of interest to industrial
society since very simple feed-stock is used, hydrogen, carbon
monoxide and sulphate for example. The fourth chapter switches
attention to a metal which became valuable later in evolution,
copper, and which is involved with the use of dioxygen. It also has
extremely interesting catalytic sites in enzymes. The essence of
the volume lies in an appreciation of metallo- enzymes and their
changing roles as the environment changed.
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Dengue (Paperback)
Rafael Elias Marques, Rodrigo Guabiraba, Daniel Cisalpino, Mauro M Teixeira
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R1,761
Discovery Miles 17 610
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Ships in 10 - 15 working days
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Dengue is a major public health concern throughout the tropical and
sub-tropical regions of the world. It is the most rapidly spreading
mosquito-borne viral disease, with a 30-fold increase in global
incidence over the past 50 years. Infection with any of the Dengue
virus serotypes can be asymptomatic, cause the classic dengue
fever, or evolve to severe disease, which leads to hypovolemic
shock and death if untreated. There is no approved specific
treatment, prognostic markers, or vaccines for dengue, in part
because there is insufficient knowledge of dengue pathogenesis. In
this e-book, we will focus on what we believe to be a true
challenge in dengue research: to understand host-pathogen
interactions. Disease development results from the interaction
between host and viral factors, in which the host immune response
is critical. Recent advances in dengue experimental models together
with clinical data have provided useful information indicating that
severe dengue hallmarks (excessive production of pro-inflammatory
cytokines, endothelial activation, and plasma leakage) are
immune-mediated events. We hope to present readers with a
comprehensive description of the immune response to the Dengue
virus, detailing how DENV unbalances host homeostasis.
Throughout recent decades, higher education has played a steadily
greater role in national development, contributing towards
heightened competitiveness and turning knowledge into a factor of
differentiation in both socio-economic and market contexts. This
book explores the state of crisis in the global higher education
realm and includes topics such as the demand and supply of higher
education which is impacting unemployment; the practice of
institutional integration; training teachers for vocational and
technical education and the fragmentation of nursing education.
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