Volume V deals with the problems of turnover in the nervous system. "Turnover" is defined in different ways, and the term is used in different contexts. It is used rather broadly in the present volume, and intentionally so. The turnover of macromolecules is only one aspect; here "turnover" in dicates the simultaneous and coordinated formation and breakdown of macromolecular species. The complexities of cerebral protein turnover are shown in a separate chapter dealing with the synthesis of proteins, in another on breakdown, and in still another on the relationship of these two (showing how the two halves of turnover are controlled). The fact that most likely the two halves of protein turnover, synthesis and breakdown, are separated spatially and the mechanisms involved are different further emphasizes the complexity of macromolecular turnover. "Turnover" is used in a different context when the turnover of a cycle is discussed; but here again a number of complex metabolic reactions have to be interrelated and controlled; some such cycles are discussed briefly in this volume, additional cycles have been discussed with metabolism, and some cycles still await elucidation or discovery.

Proceedings of the Winnipeg Conference on Human Action, held at Winnipeg, Manitoba, Canada, 9-11 May 1975

Grundsatzlich ist es Aufgabe einer Kosten-Nutzen Analyse, die Vor- und Nachteile eines Projektes, oder allgemeiner eines Vorhabens, im Vergleich mit anderen oder ahnlichen Vorhaben darzulegen und abzuwagen. Zweck der vorliegenden Untersuchung war, zunachst eine geeignete Methode fUr die Beurteilung von Kosten und Nutzen von Heilverfahren im allgemeinen 'und einer Medi kamentengruppe im besonderen zu entwickeln, sodann diese Methode an einem konkreten Beispiel, dem der Antidepres siva-Therapie, anzuwenden. Ein medizinisches Behandlungsverfahren als Gegenstand einer Kosten-Nutzen-Analyse stellt methodisch besonders interessante Probleme. Einerseits sind wirtschaftliche MaBstabe an ein individual-medizinisches Verfahren zu legen und andererseits sind dabei soziale und offentliche Faktoren moglichst gleichwertig in die Rechnung mitein zubeziehen. Die Lasung dieser Aufgabe erfordert eine Betrachtung von verschiedenen Gesichtspunkten aus. Die vorliegende Studie schien uns von aktuellem Interesse, weil nach Ubereinstimmenden Entwicklungsprognosen mit einer zunehmenden Verbreitung psychotroper Pharmaka ge rechnet werden muB, so daB dem Fragenkomplex allgemeln soziale Relevanz zukommt. Die Untergruppe der Antidepressiva stellte sich dabei sowohl aufgrund der Haufigkeit der Depression als auch wegen der relativ gut abgegrenzten therapeutischen Indi kation in den Vordergrund des Interesses."

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Embracing Special Chapters On Foods And Their Preparation; Water And Other Beverages; Air And Ventilation; The Removal Of Waste Matters; Exercise, Rest And Recreation; Bathing And Clothing; Hygiene Of The Special Senses; And The Effects Of Stimulants And Narcotics On The Human System. This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.

Embracing Special Chapters On Foods And Their Preparation; Water And Other Beverages; Air And Ventilation; The Removal Of Waste Matters; Exercise, Rest And Recreation; Bathing And Clothing; Hygiene Of The Special Senses; And The Effects Of Stimulants And Narcotics On The Human System. This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.

Embracing Special Chapters On Foods And Their Preparation; Water And Other Beverages; Air And Ventilation; The Removal Of Waste Matters; Exercise, Rest And Recreation; Bathing And Clothing; Hygiene Of The Special Senses; And The Effects Of Stimulants And Narcotics On The Human System. This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.

Embracing Special Chapters On Foods And Their Preparation; Water And Other Beverages; Air And Ventilation; The Removal Of Waste Matters; Exercise, Rest And Recreation; Bathing And Clothing; Hygiene Of The Special Senses; And The Effects Of Stimulants And Narcotics On The Human System. This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.