The economic crises of the 1970s marked the end of the 'Golden Age' of the welfare state and triggered a broad range of cost containment measures in OECD countries. In the healthcare sector the difficulties of cutting back state involvement are largely caused by the fact that the legitimacy of health systems is based on their capability to provide a satisfactory standard of healthcare for all citizens, irrespective of their ability to pay for it. Hence, the divergent healthcare system types of the heydays of the welfare state which were characterized by the distinct role of the state have now changed profoundly. Combining cross-sectional studies on healthcare financing, provision and policy values with in-depth country studies of Britain, Germany and the US, this volume argues that divergent healthcare system types are now converging toward hybrid forms.

This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.

This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.

Describes developments in healthcare systems over nearly four decades. Combining cross-sectional studies on healthcare financing, provision and policy values with in-depth country studies of Britain, Germany and the USA, this volume is a thorough examination of the convergence toward hybrid forms of healthcare systems.