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This series of concise essays on Enteroceptors is designed to
interest the gradu ate student and to stimulate research. Even
before the advent of electrophysiological studies, classical
physiological techniques had shown the essence of the role of many
of the enteroceptors. Thus the monitoring influence of the
cardiovascular mechanoreceptors on the heart and on the systemic
vascular resistance, the role of the arterial chemoreceptors in
hypoxia and the influence of the so-called Hering Breuer stretch
receptors on breathing had all been documented. The pioneering work
of ADRIAN, BRONK, ZOTTERMAN and others using electroneurographic
methods gave a remarkable impetus to the study of the enteroceptors
themselves. Nowhere is this better exemplificd than in the case of
the afferent end organs of the heart, the respiratory tract and the
abdominal and pelvic viscera. The remarkable development of our
knowledge of the multiplicity of types of nerve endings from the
thoracic and abdominal viscera acquired from electrophysiological
studies has refocussed our attention on the histological details of
the sites of such receptors. Once more research on the structural
side has been accelerated by the question raised by evidence
obtained from functional studies. This is well illustrated in the
case of the carotid body, where the long cherished belief that the
innervated epithelioid cells constitute the chemoreceptor complex
is now under attack. The detailed consideration of the functional
characteristics of each entero ceptor considered has not occupied
our whole attention."
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