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Hobbes and the Paradoxes of Political Origins (Hardcover): M. Kramer Hobbes and the Paradoxes of Political Origins (Hardcover)
M. Kramer
R2,769 Discovery Miles 27 690 Ships in 10 - 15 working days

This book expounds an analytical method that focuses on paradoxes - a method originally associated with deconstructive philosophy, but bearing little resemblance to the interpretive techniques that have come to be designated as 'deconstruction' in literary studies. The book then applies its paradox-focused method as it undertakes a sustained investigation of Thomas Hobbe's political philosophy. Hobbes's theory of the advent and purpose of government turns out to reveal the impossibility of the very developments which it portrays as indispensable.

Hobbes and the Paradoxes of Political Origins (Hardcover, 1997 ed.): M. Kramer Hobbes and the Paradoxes of Political Origins (Hardcover, 1997 ed.)
M. Kramer
R2,769 Discovery Miles 27 690 Ships in 10 - 15 working days

This book expounds an analytical method that focuses on paradoxes - a method originally associated with deconstructive philosophy, but bearing little resemblance to the interpretive techniques that have come to be designated as 'deconstruction' in literary studies. The book then applies its paradox-focused method as it undertakes a sustained investigation of Thomas Hobbe's political philosophy. Hobbes's theory of the advent and purpose of government turns out to reveal the impossibility of the very developments which it portrays as indispensable.

Mental Health, Racism and Sexism (Hardcover): Charles Vert Willie, Patricia Perri Rieker, Bernard M. Kramer, Bertram S. Brown Mental Health, Racism and Sexism (Hardcover)
Charles Vert Willie, Patricia Perri Rieker, Bernard M. Kramer, Bertram S. Brown
R4,995 Discovery Miles 49 950 Ships in 12 - 17 working days

Following their book "Racism and Mental Health", the authors here re-examine the intersections of racism and mental health, adding sexism as another divisive issue that profoundly affects mental health. The book aims to offer fresh perspectives on contemporary controversial issues, including: interracial adoptions, teenage motherhood, gender bias in mental health diagnosis and therapy, prisons used as substitutes for hospitals, homeless families, and increasing violence in the home and on the streets.

In the Realm of Legal and Moral Philosophy - Critical Encounters (Hardcover): M. Kramer In the Realm of Legal and Moral Philosophy - Critical Encounters (Hardcover)
M. Kramer
R2,783 Discovery Miles 27 830 Ships in 10 - 15 working days

In this wide-ranging investigation of many prominent issues in contemporary legal, political, and moral philosophy, Matthew Kramer combines penetrating critiques with original theorising as he examines the writings of numerous major theorists (including Ronald Dworkin, H.L.A. Hart, Alan Gewirth, Ronald Coase and Richard Posner). Among the many topics covered by Kramer's essays are the relative merits of legal positivism and natural-law theory, the appropriate understanding of justice, the role of consequences in moral decision-making, and the ultimate foundations of moral judgements.

H.L.A. Hart (Paperback): M. Kramer H.L.A. Hart (Paperback)
M. Kramer
R561 Discovery Miles 5 610 Ships in 12 - 17 working days

H.L.A. Hart is among the most important philosophers of the twentieth century, with an especially great influence on the philosophy of law. His 1961 book The Concept of Law has become an enduring classic of legal philosophy, and has also left a significant imprint on moral and political philosophy. In this volume, leading contemporary legal and political philosopher Matthew H. Kramer provides a crystal-clear analysis of Hart's contributions to our understanding of the nature of law. He elucidates and scrutinizes every major aspect of Hart's jurisprudential thinking, ranging from his general methodology to his defense of legal positivism. He shows how Hart's achievement in The Concept of Law, despite the evolution of debates in subsequent decades, remains central to contemporary legal philosophy because it lends itself to being reinterpreted in light of new concerns and interests. Kramer therefore pays particular attention to the strength of Hart's insights in the context of present-day disputes among philosophers over the reality of normative entities and properties and over the semantics of normative statements. This book is an invaluable guide to Hart's thought for students and scholars of legal philosophy and jurisprudence, as well as moral and political philosophy.

Saving and Investment in the Twenty-First Century - The Great Divergence (Hardcover, 2021 ed.): Carl Christian Von Weizsacker,... Saving and Investment in the Twenty-First Century - The Great Divergence (Hardcover, 2021 ed.)
Carl Christian Von Weizsacker, Hagen M. Kramer
R1,590 Discovery Miles 15 900 Ships in 12 - 17 working days
Large Hadron Collider Phenomenology (Paperback): M. Kramer, F. J. P. Soler Large Hadron Collider Phenomenology (Paperback)
M. Kramer, F. J. P. Soler
R939 Discovery Miles 9 390 Ships in 12 - 17 working days

With the Large Hadron Collider (LHC) under construction and due to come online in 2007, it is appropriate to engage in a focused review on LHC phenomenology. At a time when most of the experimental effort is centered on detector construction and software development, it is vitally important to direct the experimental community and, in particular, new researchers on the physics phenomena expected from the LHC. Large Hadron Collider Phenomenology covers the capabilities of LHC, from searches for the Higgs boson and physics beyond the standard model to detailed studies of quantum chromodynamics, the B-physics sectors, and the properties of hadronic matter at high energy density as realized in heavy-ion collisions. Written by experienced researchers and experimentalists, this reference examines the basic properties and potentials of the machine, detectors, and software required for physics analyses. The book starts with a basic introduction to the standard model and its applications to the phenomena observed at high energy collisions. Later chapters describe the key technological challenges facing the construction of the LHC machine, the operating detectors of the LHC, and the vast computing grid needed to analyze the data. In the final sections, the contributors discuss the quark-gluon plasma (QGP), explore questions and predictions for the LHC program, and examine the physics opportunities of the LHC using information from the forward region. By surveying the difficult challenges of the LHC development while also assessing the novel processes that the LHC will perform, Large Hadron Collider Phenomenology aids less seasoned physicists as well as existing researchers in discovering the numerous possibilities of the LHC.

Research in Organizational Behavior, Volume 24 (Hardcover): Barry Staw, Roderick M. Kramer Research in Organizational Behavior, Volume 24 (Hardcover)
Barry Staw, Roderick M. Kramer
R2,254 Discovery Miles 22 540 Ships in 12 - 17 working days

The chapters in this collection address a variety of concerns in organizational theory, ranging from the evolution of organizations and cross-cultural analyses of managerial behavior to the micro-sociology of knowledge brokering within organizations and the etiology of organizational messes. Swaminathan, examines resource partitioning theory, an important theoretical perspective in population ecology. The next three chapters, broadly construed, address issues of organizational innovation, learning, and adaptation in complex environments. The next contribution, by John Carroll, Jenny Rudolph, and Sachi Hatakenaka examines how high-hazard organizations learn from experience. As with all organizations, high-hazard organizations such as nuclear power plants and chemical plants attempt to learn from experience in order to improve performance and, of course, to avoid catastrophic failure. Unlike many other kinds of organizations, however, failure to learn from prior experience-especially with respect to learning effectively from errors and mishaps-can prove extremely costly and even fatal. Hence, these organizations must balance between learning and control, and must do so under conditions of considerable oversight and scrutiny. provocative analysis of the role disorganization plays in organizational life. The two following chapters in this volume provide important overviews of theory and research on classic phenomena within organizational theory, followed by original theoretical syntheses. Robert Baron's chapter then undertakes a fresh and useful examination of the burgeoning literature on entrepreneurship and the two final chapters in the volume examine essential issues related to our understanding of organizations and the cultural environments in which they are embedded.

Social Decision Making - Social Dilemmas, Social Values, and Ethical Judgments (Paperback): Roderick M. Kramer, Ann E.... Social Decision Making - Social Dilemmas, Social Values, and Ethical Judgments (Paperback)
Roderick M. Kramer, Ann E. Tenbrunsel, Max H. Bazerman
R1,604 Discovery Miles 16 040 Ships in 12 - 17 working days

This book, in honor of David Messick, is about social decisions and the role cooperation plays in social life. Noted contributors who worked with Dave over the years will discuss their work in social judgment, decision making and ethics which was so important to Dave. The book offers a unique and valuable contribution to the fields of social psychology and organizational behavior. Ethical decision making, a central focus of this volume, is highly relevant to current scholarship and research in both disciplines. The volume will be suitable for graduate level courses in organizational behavior, social psychology, business ethics, and sociology.

Research in Organizational Behavior, Volume 25 (Hardcover, New): Roderick M. Kramer, Barry Staw Research in Organizational Behavior, Volume 25 (Hardcover, New)
Roderick M. Kramer, Barry Staw
R2,294 Discovery Miles 22 940 Ships in 12 - 17 working days

This volume celebrates the first quarter century of publishing Research in Organizational Behavior. From its inception, Research in Organizational Behavior has striven to provide important theoretical integrations of major literatures in the organizational sciences, as well as timely examination and provocative analyses of pressing organizational issues and problems.
In keeping with this tradition, the current volume offers an eclectic mix of scholarly articles that address a variety of important questions in organizational theory and do so from a diverse range of disciplinary perspectives and theoretical orientations. A number of the chapters also directly engage contemporary events and dilemmas of considerable importance.

Organizational Trust - A Reader (Hardcover, New): Roderick M. Kramer Organizational Trust - A Reader (Hardcover, New)
Roderick M. Kramer
R6,366 R6,038 Discovery Miles 60 380 Save R328 (5%) Ships in 12 - 17 working days

Organizational trust is a subject which has over the past decade become of increasing importance to organizational theory and research. This book examines what trust is, how it is developed and maintained, its underpinnings, manifestations, and its fragility, through a presentation and discussion of key readings.

Power and Influence in Organizations (Hardcover): Roderick M. Kramer, Margaret A. Neale Power and Influence in Organizations (Hardcover)
Roderick M. Kramer, Margaret A. Neale
R5,119 Discovery Miles 51 190 Ships in 12 - 17 working days

This volume is a readily accessible compilation of current, original research in the area of power and influence in organizations. Power and Influence in Organizations offers a rich exploration of emerging trends and new perspectives. Contributors include leading scholars in organizational behavior and theory and major contemporary intellectual pioneers in research on power and influence, including Samuel B. Bacharach, Robert Cialdini, Edward J. Lawler, and Jeffrey Pfeffer. Each contributor provides insight into his or her own research, an overview of general trends, and thoughts about the direction of future research. Topics examined include manipulation of employee perceptions and values; the links between power and accountability; sharing power; the effects of gender on power and influence; illusions of influence; and impression management. Advanced students and scholars in organizational behavior, social influence, power and politics, conflict management, and institutional politics will find Power and Influence in Organizations stimulating and a useful roadmap to present and future research.

A Woman's Guide to Heart Attack Recovery - How to Survive, Thrive, and Protect Your Heart (Paperback): Harvey M. Kramer,... A Woman's Guide to Heart Attack Recovery - How to Survive, Thrive, and Protect Your Heart (Paperback)
Harvey M. Kramer, Charlotte Libov
R319 Discovery Miles 3 190 Ships in 12 - 17 working days

As a heart attack survivor, you know that you must do everything within your power to prevent yourself from having another heart attack. The reason is simple; as a heart attack survivor, you are at greater risk of suffering another heart attack, one that could end your life. A Woman's Guide to Heart Attack Recovery provides heart attack survivors with a multi-faceted approach to preventing subsequent heart attacks. First, you need to empower yourself, and the way to do that is to learn as much as you can about your heart, the heart attack treatments you may have undergone, and, if you've only recently had your heart attack, the key steps to recuperation. You also need to know what to do in an emergency in case you experience another heart attack. Many chapters in this book - such as the ones on high blood pressure, diabetes, weight control, diet and exercise - are filled with information on how to achieve these specific goals. A heart attack can be a life-affirming wake-up call and many women find their life afterward to be better than it was before. Many of you will find it to be the impetus you need to make changes towards living a healthier life. A Women's Guide to Heart Attack Recovery is devoted to helping you do just that.

Large Hadron Collider Phenomenology (Hardcover): M. Kramer, F. J. P. Soler Large Hadron Collider Phenomenology (Hardcover)
M. Kramer, F. J. P. Soler
R6,310 Discovery Miles 63 100 Ships in 12 - 17 working days

With the Large Hadron Collider (LHC) under construction and due to come online in 2007, it is appropriate to engage in a focused review on LHC phenomenology. At a time when most of the experimental effort is centered on detector construction and software development, it is vitally important to direct the experimental community and, in particular, new researchers on the physics phenomena expected from the LHC. Large Hadron Collider Phenomenology covers the capabilities of LHC, from searches for the Higgs boson and physics beyond the standard model to detailed studies of quantum chromodynamics, the B-physics sectors, and the properties of hadronic matter at high energy density as realized in heavy-ion collisions.
Written by experienced researchers and experimentalists, this reference examines the basic properties and potentials of the machine, detectors, and software required for physics analyses. The book starts with a basic introduction to the standard model and its applications to the phenomena observed at high energy collisions. Later chapters describe the key technological challenges facing the construction of the LHC machine, the operating detectors of the LHC, and the vast computing grid needed to analyze the data. In the final sections, the contributors discuss the quark-gluon plasma (QGP), explore questions and predictions for the LHC program, and examine the physics opportunities of the LHC using information from the forward region.
By surveying the difficult challenges of the LHC development while also assessing the novel processes that the LHC will perform, Large Hadron Collider Phenomenology aids less seasoned physicists as well as existing researchers in discovering the numerous possibilities of the LHC.

The Psychology of Leadership - New Perspectives and Research (Hardcover, New): David M. Messick, Roderick M. Kramer The Psychology of Leadership - New Perspectives and Research (Hardcover, New)
David M. Messick, Roderick M. Kramer
R4,434 Discovery Miles 44 340 Ships in 12 - 17 working days

In this book, some of the world's leading scholars come together to describe their thinking and research on the topic of the psychology of leadership. Most of the chapters were originally presented as papers at a research conference held in 2001 at the Kellogg School of Management of Northwestern University. The contributions span traditional social psychological areas, as well as organizational theory; examining leadership as a psychological process and as afforded by organizational constraints and opportunities. The editors' goal was not to focus the chapters on a single approach to the study and conceptualization of leadership but rather to display the diversity of issues that surround the topic.
Leadership scholars have identified a host of approaches to the study of leadership. What are the personal characteristics of leaders? What is the nature of the relation between leaders and followers? Why do we perceive some people to be better leaders than others? What are the circumstances that evoke leadership qualities in people? Can leadership be taught? And so on. The contributions to this book examine these important questions and fall into three categories: conceptions of leadership, factors that influence the effectiveness of leadership, and the consequences and effects of leadership on the leader. All in all, the chapters of this volume display part of a broad spectrum of novel and important approaches to the study of the psychology of leadership. We hope that they are equally useful to those who are or would be leaders and to those who study the topic. As recent events have served to remind us, it is too important a topic to be ignored by psychologists.

Directory of World Cinema: Argentina (Paperback): Gary M Kramer, Beatriz Urraca Directory of World Cinema: Argentina (Paperback)
Gary M Kramer, Beatriz Urraca
R1,355 Discovery Miles 13 550 Ships in 12 - 17 working days

Argentina boasts one of the most popular, diverse, and successful film industries in Latin America. From early films about gauchos and the tango to human rights dramas and groundbreaking experimental documentaries, Argentina's cinematic output has achieved both global influence and international acclaim.
A discriminating survey of the country's key films, "Directory of World Cinema: Argentina" contains provocative essays and astute reviews by scholars, critics, filmmakers, and film buffs. Chapters spotlight, among other subjects, the Buenos Aires film festival and the legacy of such iconic directors as Maria Luisa Bemberg and Pablo Trapero. Film reviews examine a cross-section of Argentine cinema, providing critical analysis of everything from contemporary blockbusters to hidden gems. Featuring full-color stills, interviews, references, and trivia, this book is an invaluable resource for readers interested in the fascinating world of Argentine film.

Handbook of Pulsar Astronomy (Paperback): D. R. Lorimer, M. Kramer Handbook of Pulsar Astronomy (Paperback)
D. R. Lorimer, M. Kramer
R1,435 Discovery Miles 14 350 Ships in 12 - 17 working days

Radio pulsars are rapidly rotating highly magnetized neutron stars. Studies of these fascinating objects have provided applications in solid-state physics, general relativity, galactic astronomy, astrometry, planetary physics and even cosmology. Most of these applications and much of what we know about neutron stars are derived from single-dish radio observations using state-of-the-art receivers and data acquisition systems. This comprehensive 2004 book is a unique resource that brings together the key observational techniques, background information and a review of results, including the discovery of a double pulsar system. Useful software tools are provided which can be used to analyse example data, made available on a related website. This work will be of great value not only to graduate students but also to researchers wishing to carry out and interpret a wide variety of radio pulsar observations.

The Psychology of Leadership - New Perspectives and Research (Paperback, Perennial): David M. Messick, Roderick M. Kramer The Psychology of Leadership - New Perspectives and Research (Paperback, Perennial)
David M. Messick, Roderick M. Kramer
R1,692 Discovery Miles 16 920 Ships in 12 - 17 working days

In this book, some of the world's leading scholars come together to describe their thinking and research on the topic of the psychology of leadership. Most of the chapters were originally presented as papers at a research conference held in 2001 at the Kellogg School of Management of Northwestern University. The contributions span traditional social psychological areas, as well as organizational theory; examining leadership as a psychological process and as afforded by organizational constraints and opportunities. The editors' goal was not to focus the chapters on a single approach to the study and conceptualization of leadership but rather to display the diversity of issues that surround the topic.
Leadership scholars have identified a host of approaches to the study of leadership. What are the personal characteristics of leaders? What is the nature of the relation between leaders and followers? Why do we perceive some people to be better leaders than others? What are the circumstances that evoke leadership qualities in people? Can leadership be taught? And so on. The contributions to this book examine these important questions and fall into three categories: conceptions of leadership, factors that influence the effectiveness of leadership, and the consequences and effects of leadership on the leader. All in all, the chapters of this volume display part of a broad spectrum of novel and important approaches to the study of the psychology of leadership. We hope that they are equally useful to those who are or would be leaders and to those who study the topic. As recent events have served to remind us, it is too important a topic to be ignored by psychologists.

The Psychology of the Social Self (Paperback): Tom R. Tyler, Roderick M. Kramer, Oliver P. John The Psychology of the Social Self (Paperback)
Tom R. Tyler, Roderick M. Kramer, Oliver P. John
R1,595 Discovery Miles 15 950 Ships in 12 - 17 working days

Leading theoreticians and researchers present current thinking about the role played by group memberships in people's sense of who they are and what they are worth. The chapters build on the assumption, developed out of social identity theory, that people create a social self that both defines them and shapes their attitudes and behaviors. The authors address new developments in the theoretical frameworks through which we understand the social self, recent research on the nature of the social self, and recent findings about the influence of social context upon the development and maintenance of the social self.

Directory of World Cinema: Argentina 2 (Paperback): Gary M Kramer, Beatriz Urraca Directory of World Cinema: Argentina 2 (Paperback)
Gary M Kramer, Beatriz Urraca
R1,355 Discovery Miles 13 550 Ships in 12 - 17 working days

This volume continues the exploration of contemporary Argentine cinema that began in the first book. It provides a close analysis of exciting new directors, including Marco Berger and Matias Pineiro, transnational stars like Ricardo Darin, and trends such as films made in the provinces. Contributors cover several of the country's Oscar submissions, including Benjamin Avila's Clandestine Childhood, Lucia Puenzo's The German Doctor and Damian Szifron's Wild Tales, which became a surprise global hit. Focusing primarily on films being made since 2000, the book offers a rich mix of reviews, essays, analyses and film stills, which together make it an invaluable companion to one of the most popular, diverse and successful film industries in Latin America.

Eliot, James and the Fictional Self - A Study in Character and Narration (Paperback, 1st ed. 1986): Richard Freadman, Roderick... Eliot, James and the Fictional Self - A Study in Character and Narration (Paperback, 1st ed. 1986)
Richard Freadman, Roderick M. Kramer
R915 Discovery Miles 9 150 Ships in 10 - 15 working days
Handbook of Heroism and Heroic Leadership (Hardcover): Scott T Allison, George R. Goethals, Roderick M. Kramer Handbook of Heroism and Heroic Leadership (Hardcover)
Scott T Allison, George R. Goethals, Roderick M. Kramer
R6,328 Discovery Miles 63 280 Ships in 12 - 17 working days

Over the past decade, research and theory on heroism and heroic leadership has greatly expanded, providing new insights on heroic behavior. The Handbook of Heroism and Heroic Leadership brings together new scholarship in this burgeoning field to build an important foundation for further multidisciplinary developments. In its three parts, "Origins of Heroism," "Types of Heroism," and "Processes of Heroism," distinguished social scientists and researchers explore topics such as morality, resilience, courage, empathy, meaning, altruism, spirituality, and transformation. This handbook provides a much-needed consolidation and synthesis for heroism and heroic leadership scholars and graduate students.

Saving and Investment in the Twenty-First Century - The Great Divergence (Paperback, 1st ed. 2021): Carl Christian Von... Saving and Investment in the Twenty-First Century - The Great Divergence (Paperback, 1st ed. 2021)
Carl Christian Von Weizsacker, Hagen M. Kramer
R1,370 Discovery Miles 13 700 Ships in 10 - 15 working days

The economy of the 21st century in the OECD countries and in China, is characterized by a new phenomenon: the structural surplus of private savings in relation to private investment. This is true even in a situation of prosperity and very low interest rates. On the one hand, this excess saving is due to people's increasing inclination to save in light of rising life expectancy, driven by the desire to have sufficient assets in old age. On the other hand, the demand for capital is not increasing to the same extent, so that investment is not keeping pace with the rising desire to save. The resulting gap between the private desire for wealth and private investment can only be closed by increasing public debt. This open access book offers a new, capital-theoretical perspective on the macroeconomic relationship between desired wealth and investment, and it presents new empirical data on private wealth and its composition in the OECD plus China area. The authors argue that a free economic and social order can only be stabilized if the wealth aspirations of individuals are met under conditions of price stability. This is not possible without substantial net public debt. A new way of thinking about the economy as a whole is required. By way of an in-depth theoretical and empirical analysis, the book demonstrates this new way of thinking and describes the current challenges facing economic policy. It will appeal to economists and students of economics who are interested in macroeconomic theory and its economic policy implications. An impressive, and convincing theoretical dive into the fundamentals behind secular stagnation, with very strong implications for actual debt policy. Public debt may be needed to improve welfare. - Olivier Blanchard, Senior Fellow at the Peterson Institute for International Economics and Professor of Economics Emeritus at Massachusetts Institute of Technology (MIT). Chief Economist at the International Monetary Fund from 2008 to 2015. Saving and Investment in the Twenty-First Century gives a wholly new perspective on macroeconomics. (...) Weiz sacker and Kramer describe a simple, practical solution to the underemployment that has plagued Southern Europe for more than a decade. - George Akerlof, Nobel Laureate in Economics, 2001. Professor at the McCourt School of Public Policy at Georgetown University and Professor of Economics Emeritus at the University of California, Berkeley. This is a profound and original contribution that can help us to understand and act on the great issues of our times. - Nicholas Stern, Grantham Research Institute on Climate Change and the Environment at the London School of Economics. Author of the Stern Review Report on the Economics of Climate Change. Chief Economist at the World Bank from 2000 to 2003.

Rights, Wrongs and Responsibilities (Paperback, 1st ed. 2001): M. Kramer Rights, Wrongs and Responsibilities (Paperback, 1st ed. 2001)
M. Kramer
R1,321 R1,223 Discovery Miles 12 230 Save R98 (7%) Ships in 9 - 15 working days

In this wide-ranging investigation of many prominent issues in contemporary legal and political philosophy, eight distinguished philosophers and legal theorists (including Matthew Kramer, Hillel Steiner, Antony Duff, Sandra Marshall, Wilfrid Waluchow, and Nicholas Bamforth) tackle issues such as the rights of animals and foetuses, the relationship between law and politics, the requirements of justice, the demands of practical rationality, the role of public-policy considerations in legal reasoning, the fundamental characteristics of legal and moral entitlements, the appropriateness of compensation as a means of rectifying mishaps and misdeeds, the extent of individuals' responsibility for the consequences of their choices, and the culpability of failed attempts to commit crimes. Together, the eight principal essays in Rights, Wrongs, and Responsibilities shed philosophical light on public law, criminal law, and most areas of private law as they explore the bearings of the three key concepts in the volume's title.

Signal Transduction (Paperback, New ed): Bastien D. Gomperts, Ijsbrand M. Kramer, Peter E.R. Tatham Signal Transduction (Paperback, New ed)
Bastien D. Gomperts, Ijsbrand M. Kramer, Peter E.R. Tatham
R1,532 Discovery Miles 15 320 Ships in 12 - 17 working days

Signal Transduction now in paperback, is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix, etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particulary cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources key observations and experiments that set the scence for recent and current work.
* Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine
* Conceptual colour artwork assists with the comprehension of key topics
* Extensive referencing provides an invaluable link to the core and historical literature
* Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms

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