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The overall scope of this new series will be to evolve an
understanding of the genetic basis of (1) how early mesoderm
commits to cells of a heart lineage that progressively and
irreversibly assemble into a segmented, primary heart tube that can
be remodeled into a four-chambered organ, and (2) how blood vessels
are derived and assembled both in the heart and in the body. Our
central aim is to establish a four-dimensional, spatiotemporal
foundation for the heart and blood vessels that can be genetically
dissected for function and mechanism. Since Robert DeHaan's seminal
chapter "Morphogenesis of the Vertebrate Heart" published in
Organogenesis (Holt Rinehart & Winston, NY) in 1965, there have
been surprisingly few books devoted to the subject of
cardiovascular morpho genesis, despite the enormous growth of
interest that occurred nationally and inter nationally. Most
writings on the subject have been scholarly compilations of the
proceedings of major national or international symposia or multi
authored volumes, without a specific theme. What is missing are the
unifying concepts that can often make sense out of a burgeoning
database of facts. The Editorial Board of this new series believes
the time has come for a book series dedicated to cardiovascular mor
not only as an important archival and didactic reference phogenesis
that will serve source for those who have recently come into the
field but also as a guide to the evo lution of a field that is
clearly coming of age.
The overall scope of this new series will be to evolve an
understanding of the genetic basis of (1) how early mesoderm
commits to cells of a heart lineage that progressively and
irreversibly assemble into a segmented, primary heart tube that can
be remodeled into a four-chambered organ, and (2) how blood vessels
are derived and assembled both in the heart and in the body. Our
central aim is to establish a four-dimensional, spatiotemporal
foundation for the heart and blood vessels that can be genetically
dissected for function and mechanism. Since Robert DeHaan's seminal
chapter "Morphogenesis of the Vertebrate Heart" published in
Organogenesis (Holt Rinehart & Winston, NY) in 1965, there have
been surprisingly few books devoted to the subject of
cardiovascular morpho genesis, despite the enormous growth of
interest that occurred nationally and inter nationally. Most
writings on the subject have been scholarly compilations of the
proceedings of major national or international symposia or multi
authored volumes, without a specific theme. What is missing are the
unifying concepts that can often make sense out of a burgeoning
database of facts. The Editorial Board of this new series believes
the time has come for a book series dedicated to cardiovascular mor
not only as an important archival and didactic reference phogenesis
that will serve source for those who have recently come into the
field but also as a guide to the evo lution of a field that is
clearly coming of age.
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